REVIEW PAPER
Yersiniosis – zoonotic foodborne disease of relevance to public health
 
More details
Hide details
1
Department of Epizootiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Poland
 
 
Ann Agric Environ Med. 2015;22(3):397-402
 
KEYWORDS
ABSTRACT
Introduction:
Y. enterocolitica is the causative agent of yersiniosis – a foodborne zoonosis with substantial importance to public health. Y. enterocolitica is widespread in the environment and animal populations, posing a potential source of infection to humans.

Objective.:
Presentation of yersiniosis as a zoonotic foodborne disease of relevance to public health.

State of knowledge:
Swine play an important role as a reservoir of Y. enterocolitica and insufficiently thermally processed pork is the main source of infection to humans. The correlation between strains isolated from pigs and from clinical cases of human yersiniosis has been sufficiently proven. Yersiniosis usually appears with gastrointestinal disturbances in children, whereas in adults it manifests in a pseudo-appendix form. The extra-enteric form of yersiniosis is rare. Classical bacteriological methods used for classifying Y. enterocolitica as pathogenic does not take into account the new aspects of the pathogenesis of yersiniosis. The examples are biotype 1A strains, commonly regarded as non-pathogenic, although they are increasingly often isolated from clinical cases of yersiniosis. Molecular methods seem much more effective and accurate in the diagnostic. New diagnostic tools such as real-time PCR, allows not only qualitative examination, but also quantitative evaluation of genes expression level, or single nucleotide polymorphism detection.

Conclusions:
Yersiniosis is an important food-borne zoonosis with wide range of clinical symptoms. Considering the fact that pork is the main source of infection for humans, public information campaigns seems to be an important element of the preventive measures against Y. enterocolitica infections.

REFERENCES (51)
1.
European Food Safety Authority. The European Union Summary Report on Trends and Sources of Zoonoses, Zoonotic Agents and Food-borne Outbreaks in 2011. EFSA Journal. 2013; 11: 3129–3379. doi: 10.2903/j.efsa.2013.3129.
 
2.
Furman S, Sadkowska-Todys M. Yersiniosis in Poland in 2011. Przegl Epidemiol. 2013; 67: 221–225.
 
3.
Kamińska S, Sadkowska-Todys M. Yersiniosis in Poland in 2012. Przegl Epidemiol. 2014; 68: 235–238.
 
4.
Huovinen E, Sihvonen LM, Virtanen MJ, Haukka K, Siitonen A, Kuusi M. Symptoms and sources of Yersinia enterocolitica-infection: a case-control study. BMC Infect Dis. 2010; 10: 122.
 
5.
Bucher M, Meyer C, Grötzbach B, Wacheck S, Stolle A, Fredriksson-Ahomaa M. Epidemiological Data on Pathogenic Yersinia enterocolitica in Southern Germany During 2000–2006. Foodborne Pathog Dis. 2008; 5: 273–280.
 
6.
Sabina Y, Rahman A, Ramesh ChR, Montet D. Yersinia enterocolitica: Mode of Transmission, Molecular Insights of Virulence, and Pathogenesis of Infection. J Pathog. 2011; doi: 10.4061/2011/429069.
 
7.
Neubauer H, Aleksic S, Hensel A, Finke EJ, Meyer H. Yersinia enterocolitica 16S rRNA gene types belong to the same genospecies but form three homology groups. Int J Med Microbiol. 2000; 290: 61–64.
 
8.
Bhagat N, Virdi JS. Distribution of virulence-associated genes in Yersinia enterocolitica biovar 1A correlates with clonal groups and not the source of isolation. FEMS Microbiol Lett. 2007; 266: 177–183.
 
9.
Batzilla J, Heesemann J, Rakin A. The pathogenic potential of Yersinia enterocolitica 1A. Int J Med Microbiol. 2011; 301(7): 556–561.
 
10.
Gierczyński R. Evaluation of the usefulness of selected virulence markers for identification of virulent Yersinia enterocolitica strains. II. Genotypic markers associated with the pYV plasmid. Med Dośw Mikrobiol. 2000; 52: 35–49.
 
11.
Gierczyński R. Evaluation of the usefulness of selected virulence markers for identification of virulent Yersinia enterocolitica strains. III. Chromosome markers of virulence. Med Dośw Mikrobiol. 2000; 52: 51–65.
 
12.
Tennant SM, Skinner NA, Joe A, Robins-Browne RM. Homologues of Insecticidal Toxin Complex Genes in Yersinia enterocolitica Biotype 1A and Their Contribution to Virulence. Infect Immun. 2005; 73: 6860–6867.
 
13.
Singh I, Virdi JS. Production of Yersinia stable toxin (YST) and distribution of yst genes in biotype 1A strains of Yersinia enterocolitica. J Med Microbiol. 2004; 53: 1065–1068.
 
14.
Ramamurthy T, Yoshino KI, Huang X, Balakrish Nair G, Carniel E, Maruyama T, Fukushima H, Takeda T. The novel heat-stable enterotoxin subtype gene (ystB) of Yersinia enterocolitica: nucleotide sequence and distribution of the yst genes. Microb Pathog. 1997; 23: 189–200.
 
15.
Kuehni-Boghenbor K, On SLW, Kokotovic B, Baumgartner A, Wassenaar TM, Wittwer M, Bissig-Choisat B, Frey J. Genotyping of Human and Porcine Yersinia enterocolitica, Yersinia intermedia, and Yersinia bercovieri Strains from Switzerland by Amplified Fragment Length Polymorphism Analysis. Appl Environ Microbiol. 2006; 6: 4061–4066.
 
16.
Fosse J, Seegers H, Magras C. Prevalence and Risk Factors for Bacterial Food-Borne Zoonotic Hazards in Slaughter Pigs: A Review. Zoonoses Public Health 2009; 56: 429–454.
 
17.
Laukkanen-Ninios R, Fredriksson-Ahomaa M, Korkeala H. Enteropathogenic Yersinia in the Pork Production Chain: Challenges for Control. Compr Rev Food Sci F. 2014; 13: 1165–1191.
 
18.
Swaminathan B, Harmon MC, Mehlman IJ. Yersinia enterocolitica. J Appl Bacteriol. 1982; 52: 151–183.
 
19.
Francis DW, Spaulding PL, Lovett J. Enterotoxin production and thermal resistance of Yersinia enterocolitica in milk. Appl Environ Microbiol. 1980; 40: 174–176.
 
20.
Handbook of Foodborne Pathogenic Microorganisms http://www.fda.gov/downloads/F... (access: 2014.11.03).
 
21.
Bancerz-Kisiel A, Szczerba-Turek A, Platt-Samoraj A, Socha P, Szweda W. Application of multiplex PCR for the evaluation of the occurrence of ail, ystA and ystB genes in Yersinia enterocolitica strains isolated from wild boars (Sus scrofa). Bull Vet Inst Pulawy. 2009; 53: 351–355.
 
22.
Bancerz-Kisiel A, Szczerba-Turek A, Lipczyńska K, Stenzel T, Szweda W. Bioserotypes and virulence markers of Yersinia enterocolitica strains isolated from mallards (Anas platyrhynchos) and pheasants (Phasianus colchicus). J Food Prot. 2012; 75: 2219–2222.
 
23.
Bancerz-Kisiel A, Szczerba-Turek A, Platt-Samoraj A, Socha P, Szweda W. Roe deer (Capreolus capreolus) and red deer (Cervus elaphus) as an environmental reservoir and potential source of Yersinia enterocolitica infection for humans. Pol J Vet Sci. 2014; 17: 315–319.
 
24.
Carter JE, Nelson JJ. Four-month-old female infant with bloody diarrhea. Yersinia enterocolitica infection. Pediatr Infect Dis J. 2007; 26: 664–665.
 
25.
Jagielski M, Rastawicki W, Kałużewski S, Gierczyński R. Yersiniosis – unappreciated infectious disease. Przegl Epidemiol. 2002; 56: 57–64.
 
26.
Mielczarek P, Bagłaj M. Jersinioza – rzadko rozpoznawana choroba układu pokarmowego. Gastroenterologia Polska 2004; 11: 69–74 (in Polish).
 
27.
Rowicka G. Bóle brzucha sugerujące zapalenie wyrostka robaczkowego spowodowane zakażeniem bakterią Yersinia u pięciorga dzieci – opis przypadków. Ped Współcz Gastroent, Hepat i Żyw Dziecka. 2005; 7 (3): 235–237 (in Polish).
 
28.
Garwolińska H. Reaktywne zapalenie stawów wywołane pałeczkami Yersinia enterocolitica. Klinika 1994; 12: 16–18 (in Polish).
 
29.
Wang Z, Zhang Q, Lu J, Jiang F, Zhang H, Gao L, Zhao J. Identification of outer membrane porin f protein of Yersinia enterocolitica recognized by antithyrotopin receptor antibodies in Graves’ disease and determination of its epitope using mass spectrometry and bioinformatics tools. J Clin Endocrinol Metab. 2013; 95: 4012–4020.
 
30.
Rastawicki W, Szych J, Gierczyński R, Rokosz N. A dramatic increase of Yersinia enterocolitica serogroup O:8 infections in Poland. Eur J Clin Microbiol Infect Dis. 2009; 28: 535–537.
 
31.
Rastawicki W, Szych J, Rokosz N, Zacharczuk K, Gierczyński R. Seasonality of Yersinia enterocolitica bioserotype 1B/O:8 infections in Poland. Epidemiol Infect. 2013; 141(10): 2039–2042.
 
32.
Stroel E, Heesemann J, Mayer G, Peters J, Müller-Weihrich S, Emmerling P. Bacteriological and serological findings in a further case of transfusion-mediated Yersinia enterocolitica sepsis. J Clin Microbiol. 2000; 38: 2788–2790.
 
33.
Grigull L, Linderkamp C, Sander C, Schmid H, Mutschler U, Welte K, Beilken A. Multiple spleen and liver abscesses due to Yersinia enterocolitica septicemia in a child with congenital sideroblastic anemia. J Pediatr Hematol Oncol. 2005; 27: 624–626.
 
34.
Tennant SM, Grant TH, Robins-Browne RM. Pathogenicity of Yersinia enterocolitica biotype 1A. FEMS Microbiol Lett. 2003; 38: 127–137.
 
35.
Ratnam S, Mercer E, Picco B, Parsons S Butler R. A nosocomial outbreak of diarrhoea1 disease due to Yersinia enterocolitica serotype 0:5, biotype 1. J Inf Dis. 1982; 145: 242–247.
 
36.
Greenwood MH, Hooper WL. Excretion of Yersinia spp. associated with consumption of pasteurized milk. Epidemiol Infect. 1990; 104: 345–350.
 
37.
McNally A, Dalton T, La Ragione RM, Stapleton K, Manning G, Newell DG. Yersinia enterocolitica isolates of differing biotypes from humans and animals are adherent, invasive and persist in macrophages, but differ in cytokine secretion profiles in vitro. J Med Microbiol. 2006; 55: 1725–1734.
 
38.
Kot B. Fenotypowe i genotypowe cechy pałeczek Yersinia enterocolitica oraz ich znaczenie w wykrywaniu potencjalnie chorobotwórczych szczepów. Rozprawa naukowa nr 85. Wydawnictwo Akademii Podlaskiej, 2006 (in Polish).
 
39.
Platt-Samoraj A, Szweda W, Siwicki AK. Wpływ zakażeń Yersinia enterocolitica psów i kotów na występowanie jersiniozy u człowieka. Med Weter. 2000; 56(6): 379–381 (in Polish).
 
40.
PN-EN ISO 10273:2005, 2005. Microbiology of food and animal feed. Horizontal method for the detection of Microbiology of food and animal feed. Horizontal method for the detection of presumably pathogenic Yersinia enterocolitica. Polish Committee for Standardization: Polish Norm – European Norm (with appendix PN-EN ISO 10273:2005/Ap1, 2005; PN-EN ISO 10273:2005/Ap2, 2006).
 
41.
Pimbley DW, Patel PD. A review of analytical methods for the detection of bacterial toxins. Symp Ser Soc Appl Microbiol. 1998; 27: 98–109.
 
42.
Bancerz-Kisiel A, Szczerba-Turek A, Platt-Samoraj A, Szweda W. Distribution of the ymoA and ystA genes and enterotoxins Yst production by Yersinia enterocolitica strains isolated from humans and pigs. Pol J Vet Sci. 2012; 15: 609–614.
 
43.
Wang X, Qiu H, Jin D, Cui Z, Kan B, Xiao Y, et al. O:8 serotype Yersinia enterocolitica strains in China. Int J Food Microbiol. 2008; 125: 259–266.
 
44.
Böckelmann U, Dörries HH, Neus Ayuso-Gabella M, Salgot de Marçay M, Tandoi V, Levantesi C. Quantitative PCR Monitoring of Antibiotic Resistance Genes and Bacterial Pathogens in Three European Artificial Groundwater Recharge Systems. Appl Environ Microbiol. 2009; 75(1): 154–163.
 
45.
Najdenski H, Heyndrickx M, Herman L, Werbrouck H, Van Coillie E. Quantification of Yersinia enterocolitica in raw milk using Qpcr. Vet Microb. 2012; 160(3–4): 428–434.
 
46.
Lambertz ST, Nilsson C, Hallanvuo S, Lindblad M. Real-Time PCR Method for Detection of Pathogenic Yersinia enterocolitica in Food. Appl Environ Microbiol. 2008; 74(20): 6060–6067.
 
47.
Orłowska A, Smreczak M, Trębas P, Żmudziński JF. Comparison of Real Time PCR and heminested RT-PCR methods in the detection of rabies virus infection in bats, and terrestrial animals. Bull Vet Inst Pulawy. 2008; 52: 313–318.
 
48.
Wolffs P, Knutsson R, Norling B, Radstrom P. Rapid Quantification of Yersinia enterocolitica in Pork Samples by Novel Sample Preparation Method, Flotation, Prior to Real-Time PCR. J Clin Microbiol. 2004; 42(3): 1042–1047.
 
49.
Bancerz-Kisiel A, Lipczyńska K, Szczerba-Turek A, Gospodarek E, Platt-Samoraj A, Szweda W. The use of the HRM method for identifying possible mutations in the ymoA gene region and evaluating their influence on the enterotoxic properties of Y. enterocolitica strains. BMC Vet Res. 2014; 10: 207–211.
 
50.
Baumgartner A, Küffer M, Suter D, Jemmi T, Rohner P. Antimicrobial resistance of Yersinia enterocolitica strains from human patients, pigs and retail pork in Switzerland. Int J Food Microbiol. 2007; 115: 110–114.
 
51.
Galindo CL, Rosenzweig JA, Kirtley ML, Chopra AK. Pathogenesis of Y. enterocolitica and Y. pseudotuberculosis in Human Yersiniosis. J Pathog. 2011; doi: 10.4061/2011/182051.
 
eISSN:1898-2263
ISSN:1232-1966
Journals System - logo
Scroll to top