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RESEARCH PAPER
The influence of 9-day trekking in the Alps on the level of oxidative stress parameters and blood parameters in native lowlanders
1
Department of Hygiene, Medical University, Wroclaw, Poland
2
Department of Forensic Medicine, Medical University, Wroclaw, Poland
Ann Agric Environ Med. 2014;21(3):585-589
KEYWORDS
ABSTRACT
Background:
The stimuli acting on a person in a high mountain environment (such as hypobaric hypoxia with subsequent reoxygenation, physical exercise) can significantly increase oxidative stress, stimulate erythropoiesis, lead to changes in the blood count and participate in the development of altitude sickness.
Objective:
The aim was to investigate changes in haematological parameters, indicators of oxidative stress (malondialdehyde – MDA) and antioxidant defences: catalase (CAT), superoxide dismutase (SOD), and total antioxidant status (TAS) in the plasma of young, healthy people after a 9-day expedition in the Alps.
Material and Methods:
A total of 5 patients (4 men and 1 woman), members of the Wrocław Mountaineering Club, aged 24–26 years. Collection of blood samples was carried out immediately before departure and 3 days after the end of exposure to high-altitude conditions. During the expedition, the subjects were exposed to heights: 2,050–4,165 m.a.s.l., and exercise associated with climbing.
Results:
Trekking in the Alps neither caused significant changes in the parameters of red blood cells nor increased the level of oxidative stress parameters in plasma. CAT activity increased, the ratio of SOD / CAT decreased. There was also a decrease in the total number of leukocytes, mainly monocytes and basophils.
Conclusions:
9-day exposure to high-altitude conditions is not a substantial burden for the organism of young, physically active people. The increase in antioxidant capacity is sufficient to stop oxidative processes, which are severe in these conditions, and to prevent the occurrence of significant oxidative stress. Discontinuation of exposure to allergens and dust pollution clears the airways, which is indicated by the reduction in the number of monocytes and basophils.
The stimuli acting on a person in a high mountain environment (such as hypobaric hypoxia with subsequent reoxygenation, physical exercise) can significantly increase oxidative stress, stimulate erythropoiesis, lead to changes in the blood count and participate in the development of altitude sickness.
Objective:
The aim was to investigate changes in haematological parameters, indicators of oxidative stress (malondialdehyde – MDA) and antioxidant defences: catalase (CAT), superoxide dismutase (SOD), and total antioxidant status (TAS) in the plasma of young, healthy people after a 9-day expedition in the Alps.
Material and Methods:
A total of 5 patients (4 men and 1 woman), members of the Wrocław Mountaineering Club, aged 24–26 years. Collection of blood samples was carried out immediately before departure and 3 days after the end of exposure to high-altitude conditions. During the expedition, the subjects were exposed to heights: 2,050–4,165 m.a.s.l., and exercise associated with climbing.
Results:
Trekking in the Alps neither caused significant changes in the parameters of red blood cells nor increased the level of oxidative stress parameters in plasma. CAT activity increased, the ratio of SOD / CAT decreased. There was also a decrease in the total number of leukocytes, mainly monocytes and basophils.
Conclusions:
9-day exposure to high-altitude conditions is not a substantial burden for the organism of young, physically active people. The increase in antioxidant capacity is sufficient to stop oxidative processes, which are severe in these conditions, and to prevent the occurrence of significant oxidative stress. Discontinuation of exposure to allergens and dust pollution clears the airways, which is indicated by the reduction in the number of monocytes and basophils.
REFERENCES (25)
1.
Roach RC, Hackett PH. Frontiers of hypoxia research: acute mountain sickness. J Exp Biol. 2001; 204(18): 3161–3170.
2.
Bailey DM, Davies B, Young IS, Hullin DA, Seddon PS. A potential role for free radical-mediated skeletal muscle soreness in the pathology of acute mountain sickness. Aviat Space Environ Med. 2001; 72(6): 513–521.
3.
Askew EW. Nutrition and performance in hot, cold, and high altitude environments. In: Wolinsky I. (eds.). Nutririon in Exercise and Sport, third ed. CRC Press, Boca Raton, FL 1997.pp. 597–619.
4.
Huey RB, Eguskitza X. Limits to human performance: elevated risks on high mountains. J Exp Biol. 2001; 204(18): 3115–3119.
5.
Guzek JW. Patofizjologia człowieka w zarysie. Wydawnictwo Lekarskie PZWL, Warszawa 2008 (in Polish).
6.
Ashenden MJ, Gore CJ, Dobson GP, Hahn AG. Hahn Live high, train low’’ does not change the total haemoglobin mass of male endurance athletes sleeping at a simulated altitude of 3000 m for 23 nights. Eur J Appl Physiol. 1999; 80(5): 479–484.
7.
Esteva S, Pedret R, Fort N, Torrella JR, Pagès T, Viscor G. Oxidative Stress Status in rats after intermittent exposure to hypobaric hypoxia. Wilderness & Environmental Medicine 2010; 21(4): 325–331.
8.
Karagiannidis C, Hensey G, Rueckert B, Mantel PY, Ichters B, Blaser K, et al. High-altitude climate therapy reduces local airway inflammation and modulates lymphocyte activation. Scandinavian Journal of Immunology 2006; 63(4): 304–310.
9.
Straub DA, Ehmann R, Hall GL, Moeller A, Hamacher J, Frey U, et al. Correlation of nitrites in breath condensates and lung function in asthmatic children. Pediatr Allergy Immunol. 2004; 15(1): 20–25.
10.
Van Loveren H, Boonstra A, Van Dijk M, Fluitman A, Savelkoul HF, Garssen J. UV exposure alters respiratory allergic responses in mice. Photochem Photobiol. 2000; 72(2): 253–259.
11.
Pfeifeer JM, Askew EW, Roberts DE, Wood SM, Benson JE, Johnson SC, et al. Effect of antioxidant supplementation on urine and blood markers of oxidative stress during extendedmoderate-altitude training. Wilderness and Environmental Medicine 1999; 10(2): 66–74.
12.
Radak Z, Lee K, Choi W, Sunoo S, Kizaki T, Oh-ishi S, et al. Oxidative stress induced by intermittentexposure at a simulated altitude of 4000m decreases mitochondrial superoxide dismutase content in soleus muscle of rats. Eur J Appl Physiol Occup Physiol. 1994; 69(5): 392–395.
13.
Vani R, Reddy CS, Devi S. Devi Oxidative stress in erythrocytes: a study on the effect of antioxidant mixtures during intermittent exposures to high altitude. Int J Biometeorol. 2010; 54(5): 553–562.
14.
Joanny P, Steinberg J, Robach P, Richalet JP, Gortan C, Gardette B, et al. Operation Everest III (Comex’97): the effect of simulated sever hypobaric hypoxia on lipid peroxidation and antioxidant defence systems in human blood at rest and after maximal exercise. Resuscitation 2001; 49(3): 307–314.
15.
Woźniak B, Mila-Kierzenkowska C, Drewa G, Woźniak A, Kalinowski A, Drewa T, et al. Stres oksydacyjny po wysiłku fizycznym u wioślarzy różniących się wiekiem i stopniem wytrenowania. Medycyna Sportowa 2007; 23(4): 229–232 (in Polish).
16.
Vij AG, Dutta R, Satija NK. Acclimatization to oxidative stress at high altitude. High Alt Med Biol. 2005; 6(4): 301–310.
17.
Nakanishi K, Tajima F, Nakamura A, Yagura S, Ookawara T, Yamashita H, et al. Antioxidant system in hypobaric-hypoxia. J Physiol. 1995; 15(489–3): 869–876.
18.
Sinha S, Ray US, Saha M, Singh SN, Tomar OS. Antioxidant and redox status after maximal aerobic exercise at high altitude in acclimatized lowlanders and native highlanders. Eur J Appl Physiol. 2009; 106(6): 807–814.
19.
Cimen MY. Free radical metabolism in human erythrocytes. Clin Chim Acta. 2008; 390(1–2): 1–11.
20.
Johnson TE, Henderson S, Murakami S, de Castro E, de Castro SH, Cypser J, et al. Longevity gens in the nematode Caenor-hadditis elegans also mediate increased resistance to stress and prevent disease. J Inherit Metab Dis. 2002; 25(3): 197–206.
21.
Bartosz G. Druga twarz tlenu. Wolne rodniki w przyrodzie. Wydawnictwo Naukowe PWN, Warszawa 2008 (in Polish).
22.
Sinha S, Ray US, Tomar OS, Singh SN. Different adaptation patterns of antioxidant system in natives and sojourners at high altitude. Respiratory Physiology & Neurobiology 2009; 167(3): 255–260.
23.
Habdous M, Herbeth B, Vincent-Viry M, Lamont JV, Fitzgerald PS, Visvikis S, et al. Serum total antioxidant status, erythrocyte superoxide dismutase and whole-blood glutathione peroxidase activity in the Stanislas cohort: influencing factors and reference intervals. Clin Chem Lab Med. 2003; 41(2): 209–215.
24.
Matuszkiewicz A. Białka i kwas moczowy jako potencjalne zmiatacze wolnych rodników w organizmie sportowca wyczynowego. Medycyna Sportowa 2000; 5(106): 31–39 (in Polish).
25.
Pittaluga M, Parisi P, Sabatni S, Ceci R, Caporossi D, Valeria Catani M, et al. Celluar and biochemical parameters of exercise-induced oxidative stress: relationship with training levels. Free Radic Res. 2006; 40(6): 607–614.
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