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CASE REPORT
Severe carbamates intoxication of 43-year-old farmer – case report
1
Toxicology Clinic, Medical University, Lublin, Poland
2
Clinical Department of Toxicology and Cardiology, Stefan Wyszyński Regional Specialist Hospital, Lublin, Poland
Corresponding author
Ann Agric Environ Med. 2021;28(2):358-360
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Carbamate insecticides are methyl carbamic acid esters and reversible cholinesterase inhibitors. In contrast to the long-term action of organophosphate insecticides, this complex undergoes rapid hydrolysis.
Case report:
A suicidal poisoning by exposure to carbofuran in a 43-year-old farmer is reported. The patient had a sudden respiratory and cardiac arrest in the mechanism of bradycardia asystole. He was additionally diagnosed with metabolic acidosis and massive aspiration pneumonia. After applied treatment, the patient’s general condition improved – alignment of efficiency of both respiratory and circulatory efficiency were reached.
Conclusion:
Carbofuran is one of the most toxic carbamate insecticides. It is therefore important to react quickly and choose the right treatment. Differentiation between organophosphate and carbamate intoxication is essential.
Carbamate insecticides are methyl carbamic acid esters and reversible cholinesterase inhibitors. In contrast to the long-term action of organophosphate insecticides, this complex undergoes rapid hydrolysis.
Case report:
A suicidal poisoning by exposure to carbofuran in a 43-year-old farmer is reported. The patient had a sudden respiratory and cardiac arrest in the mechanism of bradycardia asystole. He was additionally diagnosed with metabolic acidosis and massive aspiration pneumonia. After applied treatment, the patient’s general condition improved – alignment of efficiency of both respiratory and circulatory efficiency were reached.
Conclusion:
Carbofuran is one of the most toxic carbamate insecticides. It is therefore important to react quickly and choose the right treatment. Differentiation between organophosphate and carbamate intoxication is essential.
REFERENCES (8)
1.
Eddleston M, Clark RF. Insecticides: Organic phosphorus compounds and carbamates, p.1409–1420; Howland MA. Atropine, p. 1425–1428 in: Hoffmann R, Howland M, Lewin N, Nelson L, Goldfrank L, Wiener S. Goldfrank’s Toxicologic Emergencies, Tenth Edition Copyright 2015 by McGraw-Hill Education.
3.
Gawlikowski T, Hubalewska-Dydejczyk A, Pach D. Acute suicidal carbofuran poisoning – case report. Przegl Lek. 2007; 64(4–5): 322–3.
4.
Clark RF. Anticholinesterase (organic phosphorus carbamate) pesticide poisoning. California poison control system https://calpoison.org/news/ant... (access: 2019.06.15).
5.
Silberman J, Taylor A. Carbamate Toxicity. [Updated 2018 Oct 27]. In: StatPearls [Internet]. Treasure Island (FL): 2019 Jan.
6.
Seńczuk W, editors. Toksykologia. Podręcznik dla studentów, lekarzy i farmaceutów. 4th ed. Warsaw: Wydawnictwo Lekarskie PZWL; 2002, p.500–502.
7.
Panasiuk L, Król M, Szponar E, Szponar J, editors. Ostre zatrucia, Wydawnictwo Lekarskie PZWL; 2009, p. 100.
8.
Brenner GM, Stevens CW. Acetylocholine receptor agonists. Pharmacology 2010, p. 71.
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