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RESEARCH PAPER
Selected routine laboratory tests in the clinical assessment of patients with obstructive sleep apnea
1
Chair and Department of Internal Medicine, Medical University, Lublin, Poland
2
Individual Specialist Medical Practice, Lublin, Poland
3
Institute of Rural Health, Lublin, Poland
4
Collegium Medicum, Jan Kochanowski University, Kielce, Poland
5
I Chair and Department of Oncological Gynaecology and Gynaecology, Independent Public Hospital No 1, Lublin, Poland
Corresponding author
Klaudia Brożyna-Tkaczyk
Chair and Department of Internal Medicine, Medical University of Lublin, Staszica 16 St., 20-081, Lublin, Poland
Chair and Department of Internal Medicine, Medical University of Lublin, Staszica 16 St., 20-081, Lublin, Poland
Ann Agric Environ Med. 2023;30(4):737-742
KEYWORDS
C-reactive proteinobstructive sleep apneafasting glucoselipid profilehaematological parametersNT-proBNPhypoxia
TOPICS
ABSTRACT
Introduction:
Obstructive sleep apnea (OSA) is a chronic disease characterized by repetitive complete or partial occlusion of the upper airways during sleep with respiratory muscle effort, which leads to consecutive apneas and hypopneas. Obstruction of the upper airways during sleep leads to repetitive episodes of disrupted airflow and consequent changes in blood oxygenation, resulting in hypoxaemia and hypercapnia. Intermittent hypoxaemia induces the production of pro-inflammatory factors and promotes metabolic dysregulation and platelet aggregation.
Objective:
The main aim of this study was to determine differences, if any, in selected standard parameters in routine laboratory tests often used in GP practice between patients with obstructive sleep apnea, without comorbidities, and a well-defined control group with the absence of this syndrome proven in polygraphic examination.
Material and methods:
Of the 192 clinically assessed persons with suspected OSA and admitted to the Internal Medicine Department in Lublin, 85 were qualified for the study after application of exclusion criteria. Demographic and health behaviour-related data, medical history regarding sleep habits and cardiovascular disease, were collected from each patient.
Results:
Apart from significantly higher MCV and MCH among the cpontrol group, no significant differences were found between patients with obstructive sleep apnea and the control group.
Conclusions:
The results can be useful for the holistic assessment of the health status of patients with newly-diagnosed OSA.
Obstructive sleep apnea (OSA) is a chronic disease characterized by repetitive complete or partial occlusion of the upper airways during sleep with respiratory muscle effort, which leads to consecutive apneas and hypopneas. Obstruction of the upper airways during sleep leads to repetitive episodes of disrupted airflow and consequent changes in blood oxygenation, resulting in hypoxaemia and hypercapnia. Intermittent hypoxaemia induces the production of pro-inflammatory factors and promotes metabolic dysregulation and platelet aggregation.
Objective:
The main aim of this study was to determine differences, if any, in selected standard parameters in routine laboratory tests often used in GP practice between patients with obstructive sleep apnea, without comorbidities, and a well-defined control group with the absence of this syndrome proven in polygraphic examination.
Material and methods:
Of the 192 clinically assessed persons with suspected OSA and admitted to the Internal Medicine Department in Lublin, 85 were qualified for the study after application of exclusion criteria. Demographic and health behaviour-related data, medical history regarding sleep habits and cardiovascular disease, were collected from each patient.
Results:
Apart from significantly higher MCV and MCH among the cpontrol group, no significant differences were found between patients with obstructive sleep apnea and the control group.
Conclusions:
The results can be useful for the holistic assessment of the health status of patients with newly-diagnosed OSA.
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