RESEARCH PAPER
Residential proximity to major roadways is associated with increased prevalence of allergic respiratory symptoms in children
 
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Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, Krakow, Poland
 
 
Ann Agric Environ Med. 2014;21(4):760-766
 
KEYWORDS
ABSTRACT
Introduction and objective:
Numerous epidemiologic studies have reported increased risk of allergic rhinitis and asthma in relation to ‘western life-style’, which represents diversity of factors. We hypothesized that residential proximity to major roadways, reflecting an exposure to traffic-related air pollution, is associated with prevalence of allergic respiratory symptoms in children.

Material and Methods:
A total of 8290 individuals of two age groups: 16 year olds and 7 year olds from Krakow, Poland were included. We used the Polish version of the International Study of Asthma and Allergy in Childhood supplemented with a question concerning the distance between a responder’s house and a high traffic density road: below 200 m, from 200–500 m, or more than 500 m.

Results:
Children and adolescents with a residential proximity closer to a major roadway had more frequent asthma-related symptoms in the last 12 months and at any time in the past. Consistent with the increased frequency of asthmatic symptoms, responders residing within 200 meters complained more often of sneezing, runny or blocked nose accompanied by itchy-watery eyes and hay fever in comparison to responders who resided 200–500 meters from a major roadway. The lowest rate of nasal symptoms was observed in residents living in the distance to major roads (>500 meters). The rate of positive answers decreased in a distant-dependent manner.

Conclusions:
Our findings suggest an important spatial relationship between the distance from a major roadway and the evaluated respiratory symptoms. The results emphasize the need for more comprehensive air quality policies within urban areas with increased motor vehicle density.

 
REFERENCES (30)
1.
Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, Weiland SK, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 2006; 368: 733–743.
 
2.
Anandan C, Nurmatov U, van Schayck OC, Sheikh A. Is the prevalence of asthma declining? Systematic review of epidemiological studies. Allergy 2010; 65(2): 152–167.
 
3.
Steinman HA, Donson H, Kawalski M, Toerien A, Potter PC. Bronchial hyper-responsiveness and atopy in urban, peri-urban and rural South African children. Pediatr Allergy Immunol. 2003; 14(5): 383–393.
 
4.
Celik G, Sin B, Keskin S, Ediger D, Bavbek S, Mungan D, et al. Risk factors determining allergic airway diseases in Turkish subjects. J Asthma. 2002; 39: 383–390.
 
5.
Heo Y, Lee WT, Lawrence DA. In vivo the environmental pollutants lead and mercury induce oligoclonal T cell responses skewed toward type-2 reactivities. Cell Immunol 1997; 179(2): 185–195.
 
6.
Spiewak R, Skorska C, Prazmo Z, Dutkiewicz J. Bacterial endotoxin associated with pollen as a potential factor aggravating pollinosis. Ann Agric Environ Med. 1996; 3(1): 57–59.
 
7.
Brauer M, Hoek G, Smit HA, de Jongste JC, Gerritsen J, Postma DS, et al. Air pollution and development of asthma, allergy and infections in a birth cohort. Eur Respir J. 2007; 29: 879–888.
 
8.
Penard-Morand C, Raherison C, Charpin D, Kopferschmitt C, Lavaud F, Caillaud D, et al. Long-term exposure to proximity air pollution and asthma and allergies in urban children. Eur Respir J. 2010; 36: 33–40.
 
9.
Penard-Morand C, Charpin D, Raherison C, Kopferschmitt C, Caillaud D, Lavaud F, et al. Long-term exposure to background air pollution related to respiratory and allergic health in schoolchildren. Clin Exp Allergy. 2005; 35: 1279–1287.
 
10.
Oftedal B, Brunekreef B, Nystad W, Nafstad P. Residential outdoor air pollution and allergen sensitization in schoolchildren in Oslo, Norway. Clin Exp Allergy. 2007; 37: 1632–1640.
 
11.
Rosenlund M, Forastiere F, Porta D, De Sario M, Badaloni C, Perucci CA. Traffic related air pollution in relation to respiratory symptoms, allergic sensitisation and lung function in schoolchildren. Thorax. 2009; 64: 573–580.
 
12.
Riedl MA. The effect of air pollution on asthma and allergy. Curr Allergy Asthma Rep. 2008; 8: 139–146.
 
13.
Muranakam M, Suzuki S, Koizumi K, Takafuji S, Miyamoto T, Ikemori R, Tokiwa H. Adjuvant activity of diesel-exhaust particulates for the production of IgE antibody in mice. J Allergy Clin Immunol. 1986; 77(4): 616–623.
 
14.
Siegel PD, Saxena RK, Saxena QB, Ma JK, Ma JY, Yin XJ, Castranova V, Al-Humadi N, Lewis DM. Effect of diesel exhaust particulate (DEP) on immune responses: contributions of particulate versus organic soluble components. J Toxicol Environ Health A. 2004; 67(3): 221–231.
 
15.
Patel MM, Hoepner L, Garfinkel R, Chillrud S, Reyes A, Quinn JW, et al. Ambient metals, elemental carbon, and wheeze and cough in New York City children through 24 months of age. Am J Respir Crit Care Med. 2009; 180: 1107–1113.
 
16.
Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez F, et al. International study of asthma and allergies in childhood (ISAAC): rationale and methods. Eur Respir J. 1995; 8 (3): 483–491.
 
17.
Devalia JL, Rusznak C, Davies RJ. Allergen/irritant interaction – its role in sensitization and allergic disease. Allergy 1998; 53 (4): 335–345.
 
18.
Sydbom A, Blomberg A, Parnia S, Stenfors N, Sandström, T, Dahlen SE. Health effects of diesel exhaust emissions. Eur Respir J. 2001; 17(4): 733–746.
 
19.
Bayram H, Devalia JL, Sapsford RJ, Ohtoshi T, Miyabara Y, Sagai M, et al. The effect of diesel exhaust particles on cell function and release of inflammatory mediators from human bronchial epithelial cells in vitro. Am J Respir Cell Mol Biol. 1998; 18 (3): 441–448.
 
20.
Spira-Cohen A, Chen LC, Kendall M, Lall R, Thurston GD. Personal exposures to traffic-related air pollution and acute respiratory health among Bronx schoolchildren with asthma. Environ Health Perspect. 2011; 119: 559–565.
 
21.
Escamilla-Nunez MC, Barraza-Villarreal A, Hernandez-Cadena L, Moreno-Macias H, Ramirez-Aguilar M, Sienra-Monge JJ, et al. Traffic-related air pollution and respiratory symptoms among asthmatic children, resident in Mexico City: the EVA cohort study. Respir Res. 2008; 9: 74.
 
22.
Ishizaki T, Koizumi K, Ikemori R, Ishiyama Y, Kushibiki E. Studies of prevalence of Japanese cedar pollinosis among the residents in a densely cultivated area. Ann Allergy. 1987; 58(4): 265–270.
 
23.
Brown MS, Sarnat SE, Demuth KA, Brown LA, Whitlock DR, Brown SW, et al. Residential proximity to a major roadway is associated with features of asthma control in children. PLoS One. 2012; 7(5): e37044.
 
24.
Dales R, Wheeler AJ, Mahmud M, Frescura AM, Liu L. The influence of neighborhood roadways on respiratory symptoms among elementary school- children. J Occup Environ Med. 2009; 51 (6): 654–660.
 
25.
Holguin F, Flores S, Ross Z, Cortez M, Molina M, Molina L, et al. Trafficrelated exposures, airway function, inflammation, and respiratory symptoms in children. Am J Respir Crit Care Med. 2007; 176: 1236–1242.
 
26.
Churg A, Brauer M, del Carmen Avila-Casado M, Fortoul TI, Wright JL. Chronic exposure to high levels of particulate air pollution and small airway remodeling. Environ Health Perspect. 2003; 111: 714–718.
 
27.
Stankiewicz-Choroszucha BL, Wawrzyniak ZM, Lipiec A, Piekarska B, Kapalczynski WJ, Samoliński BK. Consequences of smoke inhalation in the ‘Epidemiology of Allergic Diseases in Poland’ project (ECAP). Ann Agric Environ Med. 2011; 18 (2): 420–428.
 
28.
Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med. 1995; 332: 133–138.
 
29.
Li S, Batterman S, Wasilevich E, Elasaad H, Wahl R, Mukherjee B. Asthma exacerbation and proximity of residence to major roads: a population-based matched case-control study among the pediatric Medicaid population in Detroit, Michigan. Environ Health. 2011; 10: 34.
 
30.
Nuvolone D, Della Maggiore R, Maio S, Fresco R, Baldacci S, Carrozzi L, et al. Geographical information system and environmental epidemiology: a cross sectional spatial analysis of the effects of trafficrelated air pollution on population respiratory health. Environ Health. 2011; 10: 12.
 
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ISSN:1232-1966
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