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RESEARCH PAPER
Psychological factors and genetic characteristics of rural cannabis users
1
Department of Physical Education and Social Science, University of Physical Education and Sport, Gdańsk, Poland
2
Department of Hygiene and Epidemiology, Collegium Medicum, University of Zielona Góra, Poland
3
Independent Laboratory of Health Promotion of the Pomeranian Medical University, Szczecin, Poland
4
Independent Laboratory of Family Physician Education, Pomeranian Medical University, Szczeczin, Poland
5
Department of Humanities in Medicine, Pomeranian Medical University, Szczecin, Poland
Corresponding author
Anna Grzywacz
Independent Laboratory of Health Promotion of the Pomeranian Medical University in Szczecin, Chłapowskiego 11, 70-204, Szczecin, Poland
Independent Laboratory of Health Promotion of the Pomeranian Medical University in Szczecin, Chłapowskiego 11, 70-204, Szczecin, Poland
Ann Agric Environ Med. 2020;27(2):260-268
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Marijuana is one of the most widely used psychoactive substance. There is evidence of genetic predisposition for addiction.
Objective:
The aim of the study is to evaluate personality traits measured by the NEO Five-Factor Inventory and State-Trait Anxiety Inventory, combined with analysis of Tag1B rs1079597 and Tag1D rs1800498 located in the DRD2 gene.
Material and methods:
The study group consisted of 214 rural cannabinoid users and 301 controls. The same psychometric test and real-time PCR genotyping were performed in both studied groups.
Results:
The values of Anxiety state, Anxiety trait, NEO FFI: Neuroticism and Openness in the rural cannabis using group were significantly higher than in the control group. On the other hand, lower values were observed among rural people using cannabis compared to the control group for NEO FFI: Extraversion, Agreeability and Conscientiousness. In the Anxiety trait subscale, a 2% association with the polymorphism DRD2 Tag1B rs1079597 was detected in subjects using cannabis. However, for the DRD2 Tag1D rs1800498, there was no effect on the differences in personality traits between rural cannabis users and the control group.
Conclusions:
The study shows differences in personality traits between the cannabis using group and controls. Interaction between genetic factors and personality traits was also detected. The association showing the combination of psychological characteristics and genetic variants can bring us closer to the overall picture of the issue of marijuana addiction.
Marijuana is one of the most widely used psychoactive substance. There is evidence of genetic predisposition for addiction.
Objective:
The aim of the study is to evaluate personality traits measured by the NEO Five-Factor Inventory and State-Trait Anxiety Inventory, combined with analysis of Tag1B rs1079597 and Tag1D rs1800498 located in the DRD2 gene.
Material and methods:
The study group consisted of 214 rural cannabinoid users and 301 controls. The same psychometric test and real-time PCR genotyping were performed in both studied groups.
Results:
The values of Anxiety state, Anxiety trait, NEO FFI: Neuroticism and Openness in the rural cannabis using group were significantly higher than in the control group. On the other hand, lower values were observed among rural people using cannabis compared to the control group for NEO FFI: Extraversion, Agreeability and Conscientiousness. In the Anxiety trait subscale, a 2% association with the polymorphism DRD2 Tag1B rs1079597 was detected in subjects using cannabis. However, for the DRD2 Tag1D rs1800498, there was no effect on the differences in personality traits between rural cannabis users and the control group.
Conclusions:
The study shows differences in personality traits between the cannabis using group and controls. Interaction between genetic factors and personality traits was also detected. The association showing the combination of psychological characteristics and genetic variants can bring us closer to the overall picture of the issue of marijuana addiction.
ACKNOWLEDGEMENTS
This research was funded by National Science Center grant number UMO-2015/19/B/NZ7/03691.
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