REVIEW PAPER
Potential risk of exposure to selected xenobiotic residues and their fate in the food chain-part I: classification of xenobiotics.
 
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1
State Phytosanitary Administration, Section-Plant Protection Products, Brno, Czech Republic
 
2
Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University in Prague, Czech Republic
 
 
Corresponding author
Anna Iovdijová   

State Phytosanitary Administration, Section – Plant Protection Products, Zemědělská 1a, 613 00 Brno, Czech Republic
 
 
Ann Agric Environ Med. 2010;17(2):183-192
 
KEYWORDS
ABSTRACT
Consumers are exposed to a diversity of chemicals in all areas of life. Air, water, soil and food are all unavoidable components of the human environment. Each of those elements influences the quality of human life, and each of them may be contaminated. We are exposed to toxic or potentially toxic compounds in many ways in our daily lives and toxicology is clearly a subject of great importance for society. This becomes apparent when we look at the types of poisons and the ways in which we are exposed to them. Indeed, the categories cover virtually all the chemicals one might expect to encounter in the environment. After consideration of this, one might well ask Are all chemicals toxic? Phrase as an answer: There are no safe chemicals, only their safe use. Xenobiotics are defined here as those compounds, both organic and inorganic, produced by human beings and introduced into the environment, as well as into the food chain at concentrations that cause undesirable effects. Xenobiotics in the food chain are monitored in two forms: by testing - the objective of which is to discover unsuitable foodstuffs in the consumer`s network, and by monitoring - to obtain objective information about environmental components contamination and to harmlessness health of available foodstuffs.
ACKNOWLEDGEMENTS
This paper was written within the context of research activities of the 6 th Framework Programme EC DG SANCO Grant Agreement No. 2004122: “Development of Public Health Indicators for Reporting Environmental/Occupational Risks Related to Agriculture and Fishery” (DIRERAF).
 
REFERENCES (32)
1.
Altuğ T: Introduction to Toxicology and Food. CRC Press LLC, Boca Raton (Florida) 2003.
 
2.
Belitz HD, Grosch W, Schieberle P: Food Chemistry. Springer, Berlin 2009.
 
3.
Casarett LJ, Klaassen CD, Doull J: Casarett and Doull’s Toxicology: The Basic Science of Toxicology, 7 th ed. McGraw-Hill Professional, New York 2008.
 
4.
Conell DW: Bioaccumulation of Xenobiotic Compounds. CRC Press Inc., Boca Raton (Florida) 1990.
 
5.
Council Regulation (EC) No. 440/2008 of 30 May 2008 laying down test methods pursuant to Regulation (EC) No. 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH). Available from: http://eur-lex.europa.eu/JOHtm....
 
6.
Desphande SS: Handbook of Food Toxicology. CRC Press, New York 2002.
 
7.
Diechmann WB, Henschler D, Holmstead B, Geil K: What is there what is not poison? A study of the Third defence by Paracelsus. Arch Toxicol 1986, 58, 207–213.
 
8.
Eaton DL, Gilbert SG: Principles of Toxicology. In: Casarett LJ, Klaassen CD, Doull J: Casarett and Doull’s Toxicology: The Basic Science of Poisons, 7th edition. McGraw-Hill Professional, New York 2008.
 
9.
European Chemical Agency (ECHA): Practical guide 10: How to avoid unnecessary testing on animals. Helsinki 2010. Available from: http://echa.europa.eu/doc/publ....
 
10.
European Chemical Bureau, Institute for Health and Consumer Protection – European Commission, Joint Research Centre: Technical Guidance Document on Risk Assessment in support of Commission Directive 93/67/EEC on Risk Assessment for new notified substances, Commission Regulation (EC) No. 1488/94 on Risk Assessment for existing substances, Directive 98/8/EC of the European Parliament and of the Council concerning the placing of biocidal products on the market. Brussels 2003. Available from: http://ecb.jrc.ec.europa.eu/do....
 
11.
Garfield E: Journal Citation Studies. 53. Agricultural sciences: most fruitful journal and high yield research fields. Essays of an Information Scientist 1990, 13, 55. Available from: http://www.garfield.library.up....
 
12.
Hayes AW: Principles and Methods of Toxicology, 5 th ed. CRC Press, New York 2007.
 
13.
Hrudey SE, Chen W, Rousseaux CG: Bioavailability in Environmental Risk Assessment. CRC Press Inc., Boca Raton (Florida) 1996.
 
14.
Jain KK: Carbon Monoxide Poisoning. Warren H. Green, St. Louis 1990.
 
15.
Knoefel PK: Felice Fontana on Poisons. Clio Med 1980, 15, 35–66.
 
16.
Masaro EJ: Handbook of Human Toxicology. CRC Press LLC, Boca Raton (Florida) 1997.
 
17.
Murray RK, Granner DK, Rodwell VW: Harper’s Illustrated Biochemistry, 26 th ed. McGraw-Hill Professional, New York 2003.
 
18.
Murray RK, Granner DK, Mayes PA, Rodwell VW: Harper’s Illustrated Biochemistry, 27 th ed. McGraw-Hill Professional, New York 2006.
 
19.
Niyogy SK: Historic development of forensic toxicology in America up to 1978. Am J Forensic Med Pathol 1980, 1, 249 – 264.
 
20.
OECD Guidelines for Testing the Chemicals Test No. 420: Acute Oral Toxicity – Fixed Dose Procedure (UDP). Adopted: 17 September 2001. Available from: http://oberon.sourceoecd.org/v....
 
21.
OECD Guidelines for Testing the Chemicals Test No. 423: Acute Oral Toxicity – Acute Toxic Class Method. Adopted: 17 December 2001. Available from: http://oberon.sourceoecd.org/v....
 
22.
OECD Guidelines for Testing the Chemicals Test No. 425: Acute Oral Toxicity – Up-and-Down Procedure. Adopted: 17 December 2001. Available from: http://oberon.sourceoecd.org/v....
 
23.
Pachter HM: Paracelsus: Magic into Science. Collier, New York 1961.
 
24.
Pakes SP: Contribution of the laboratory animal veterinarian to refining animal experiments in toxicology. Fundam Appl Toxicol 1990, 15, 17.
 
25.
Pandit NK: Introduction to the Pharmaceutical Sciences. Lippincott Williams & Wilkins, Philadelphia 2007.
 
26.
Parkinson A, Ogilvie BW: Biotransformation of Xenobiotics. In: Casarett LJ, Klaassen CD, Doull J: Casarett and Doull’s Toxicology: The Basic Science of Poisons, 7 th ed. McGraw-Hill Professional, New York 2008.
 
27.
Rosival L, Engst R, Szokolay A: Fremd- und Zusatzstoffe in Lebensmitteln. VEB Fachbuchverlag, Leipzig 1978.
 
28.
Rosival L, Szokolay A, Bátora A, Görner F, Kaláč J, Maďarič A, Malkus Z, Polster M, Príbela M, Szokolayová J, Uhnák J, Wolf A: Foreign Chemicals in Foodstuffs. Osveta, Martin 1983 (in Czech).
 
29.
Schechtman LM: Implementation of 3R’s (refinement, reduction, and replacement): Validation and regulatory acceptance consideration for alternative toxicological test method. ILAR J 2002, Suppl. 43, S85 – S94.
 
30.
Stephens, ML: Alternatives to Current Uses of Animals in Research, Safety Testing, and Education. The Humane Society of the United States, Washington 1986.
 
31.
Timbrell JA: Introduction to Toxicology, 3 th ed. CRC Press LLC, Boca Raton (Florida) 2002.
 
32.
Thompson CJ: Poison and Poisoners. Harold Shaylor, London 1931.
 
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