RESEARCH PAPER
Plasma magnesium concentration in patients undergoing coronary artery bypass grafting
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1
Department of Anaesthesiology and Intensive Therapy Medical Universitty of Lublin, Poland
2
Department of Health Psychology, Jagiellonian University Medical College, Cracow, Poland
3
Department of Cardiac Surgery Medical University of Lublin, Poland
4
Department of General Surgery, Transplantology and Clinical Nutrition Medical University of Lublin, Poland
Corresponding author
Wojciech Dabrowski
Department of Anaesthesiology and Intensive Therapy Medical Universitty of Lublin, Poland
Ann Agric Environ Med. 2017;24(2):181-184
KEYWORDS
ABSTRACT
Introduction:
Magnesium (Mg) plays a crucial role in cell physiology and its deficiency may cause many disorders which often require intensive treatment. The aim of this study was to analyse some factors affecting preoperative plasma Mg concentration in patients undergoing coronary artery bypass grafting (CABG).
Material and Methods:
Adult patients scheduled for elective CABG with cardio-pulmonary bypass (CPB) under general anaesthesia were studied. Plasma Mg concentration was analysed before surgery in accordance with age, domicile, profession, tobacco smoking and preoperative Mg supplementation. Blood samples were obtained from the radial artery just before the administration of anaesthesia.
Results:
150 patients were studied. Mean preoperative plasma Mg concentration was 0.93 ± 0.17 mmol/L; mean concentration in patients – 1.02 ± 0.16; preoperative Mg supplementation was significantly higher than in patients without such supplementation. Moreover, intellectual workers supplemented Mg more frequently and had higher plasma Mg concentration than physical workers. Plasma Mg concentration decreases in elderly patients. Patients living in cities, on average, had the highest plasma Mg concentration. Smokers had significantly lower plasma Mg concentration than non-smokers.
Conclusions:
1. Preoperative magnesium supplementation increases its plasma concentration. 2. Intellectual workers frequently supplement magnesium. 3. Smoking cigarettes decreases plasma magnesium concentration.
REFERENCES (25)
1.
Pasternak K, Kocot J, Horecka A. Biochemistry of magnesium. J Elem 2010; 15(3): 601–616.
2.
Whang R, Hampton EM, Whang DD. Magnesium homeostasis and clinical disorders of magnesium deficiency. Ann Pharmacother 1994; 28(2): 220–226.
3.
Haigney MC, Silver B, Tanglao E, Silverman HS, Hill JD, Shapiro E et al. Noninvasive measurement of tissue magnesium and correlation with cardiac levels. Circulation 1995; 92(8): 2190–2197.
4.
Pham PC, Pham PM, Pham PA, Pham SV, Pham HV, Miller JM et al. Lower serum magnesium levels are associated with more rapid decline of renal function in patients with diabetes mellitus type 2. Clin Nephrol 2005; 63(6): 429–436.
5.
Weglicki W, Quamme G, Tucker K, Haigney M, Resnick L. Potassium, magnesium, and electrolyte imbalance and complications in disease management. Clin Exp Hypertens 2005; 27(1): 95–112.
6.
Pasternak K, Dabrowski W, Wrońska J, Rzecki Z, Biernacka J, Jurko C et al. Changes of blood magnesium concentration in patients undergoing surgical myocardial revascularisation. Magnes Res 2006; 19(2): 107–112.
7.
Polderman KH, Girbes AR. Severe electrolyte disorders following cardiac surgery: a prospective controlled observational study. Crit Care 2004; 8(6): R459–R466.
8.
Dabrowski W, Rzecki Z, Sztanke M, Visconti J, Wacinski P, Pasternak K. The efficiency of magnesium supplementation in patients undergoing cardiopulmonary bypass: changes in serum magnesium concentrations and atrial fibrillation episodes. Magnes Res 2008; 21(1): 205–217.
9.
Pasternak K, Dabrowski W, Dobija J, Wrońska J, Rzecki Z, Biernacka J. The effect of preoperative magnesium supplementation on blood catecholamine concentrations in patients undergoing CABG. Magnes Res 2006; 19(2): 113–122.
10.
Runge A. Metodologiczne problemy badania miast średnich w Polsce. Prace geograficzne zeszyt 129. IGiGP UJ Kraków 2012; 83–101.
11.
Khan AM, Lubitz SA, Sullivan LM, Sun JX, Levy D, Vasan RS et al. Low serum magnesium and the development of atrial fibrillation in the community: the Framingham Heart Study. Circulation 2013; 127(1): 33–38.
12.
Gu WJ, Wu ZJ, Wang PF, Aung LH, Yin RX. Intravenous magnesium prevents atrial fibrillation after coronary artery bypass grafting: a meta-analysis of 7 double-blind, placebo-controlled, randomized clinical trials. Trials 2012; 13: 41.
13.
Watanabe J, Nakayma S, Matsubara T, Hotta N. Regulation of intracellular free Mg+2 concentration in isolated rat hearts via β-adrenergic and muscarinic receptors. J Mol Cell Cardiol 1998; 30(11): 2307–18.
14.
Chakraborti S, Chakraborti T, Mandal M, Mandal A, Das S, Ghosh S. Protective role of magnesium in cardiovascular diseases: a review. Mol Cell Biochem 2002; 238(1–2): 163–79.
15.
Abdel-Massih TE, Sarkis A, Sleilaty G, El Rassi I, Chamandi C, Karam N et al. Myocardial extraction of intracellular magnesium and atrial fibrillation after coronary surgery. Int J Cardiol 2012; 160(2): 114–118.
16.
Furukawa Y, Kasai N, Torimitsu K. Effect of Mg +2 on neuronal activity of rat cortical and hippocampal neurons in vitro. Magnes Res 2009; 22(3): 174s–81s.
17.
Yorulmaz H, Seker FB, Demir G, Yalçın IE, Oztaş B. The effects of zinc treatment on the blood-brain barrier permeability and brain element levels during convulsions. Biol Trace Elem Res. 2013; 151(3): 256–262.
18.
Nimmo AJ, Cernak I, Heath DL, Hu X, Bennett CJ, Vink R. Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats. Neuropeptides 2004; 38(1): 40–47.
19.
Sen AP, Gulati A. Use of magnesium in traumatic brain injury. Neurotherapeutics 2010; 7(1): 91–99.
20.
Fromm L, Heath DL, Vink R, Nimmo AJ. Magnesium attenuates post-traumatic depression/anxiety following diffuse traumatic brain injury in rats. J Am Coll Nutr 2004; 23(5): 529S–533S.
21.
Pasternak K, Dabrowski W, Wyciszczok T, Korycińska A, Dobija J, Biernacka J et al. The relationship between magnesium, epinephrine and norepinephrine blood concentrations during CABG with normovolemic hemodilution. Magnes Res 2005; 18(4): 245–252.
22.
Panda NB, Bharti N, Prasad S. Minimal effective dose of magnesium sulfate for attenuation of intubation response in hypertensive patients. J Clin Anesth 2013; 25(2): 92–97.
23.
Inoue S, Akazawa S, Nakaigawa Y, Shimizu R, Seo N. Changes in plasma total and ionized magnesium concentrations and factors affecting magnesium concentrations during cardiac surgery. J Anesth 2004; 18(3): 216–219.
24.
Ichikawa S. Magnesium and calcium changes in serum and atrial muscle caused by open heart surgery and the effect of perioperative oral magnesium administration. Jpn J Thorac Cardiovasc Surg 1998; 46(3): 287–29.
25.
Satur CM, Anderson JR, Jennings A, Newton K, Martin PG, Nair U et al. Magnesium flux caused by coronary artery bypass operation: three patterns of deficiency. Ann Thorac Surg 1994; 58(6): 1674–1678.