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RESEARCH PAPER
Hyper-frontality in an OCD patient – evidence from event-related potentials in a cued GO/NOGO task
Maria Pąchalska
4,6
1
Department of Special Pedagogy, Pedagogical University, Kraków, Poland
2
Old Polish University, Kielce, Poland
3
Jan Kochanowski University, Kielce, Poland
4
Chair of Neuropsychology, Andrzej Frycz Modrzewski University, Kraków, Poland
5
Laboratory for the Neurobiology of Action Programming, Institute of the Human Brain, Russian Academy of Sciences, St. Petersburg, Russia
6
Center for Cognition and Communication, New York, NY, USA
Ann Agric Environ Med. 2016;23(2):276-279
KEYWORDS
ABSTRACT
Objective:
The study aimed to evaluate the hyperactivity of the frontal lobes in a patient with obsessive-compulsive disorders.
Case description:
A 21-year-old female met the diagnostic criteria of DSM-5 since her behaviour was characterized by a preoccupations with negative thoughts and by repetitive attempts to decrease or stop those behaviours. Two working hypotheses were tested to find neuromarkers of OCD and anxiety in the patient described. In agreement with the ‘OCD hypothesis’ an increase of the frontal beta activity and an increase of the parietalalpha activity pattern was found. The ‘anxiety’ hypothesis found confirmation in an increased left temporal P1 wave in response to the visual stimuli observed in ERPs. In all three conditions (EO, EC, GO/NOGO task), two characteristics were deviant from the normative average data in EEG spectra. First, an increase of frontal beta activity and the increase of parietal alpha activity was noted. The independent component analysis applied for 700 ms EEG fragments in GO and NOGO conditions revealed a strong activation over the central areas.
Conclusions:
pecific patterns of QEEG and ERPs, the increase of beta activity frontally, and the increase of parietal alpha activity pattern which produce hyper-frontality, might be useful in the diagnosis of an OCD patient. ERPs in a GO/NOGO task can be used in the assessment of functional brain changes in OCD patients.
The study aimed to evaluate the hyperactivity of the frontal lobes in a patient with obsessive-compulsive disorders.
Case description:
A 21-year-old female met the diagnostic criteria of DSM-5 since her behaviour was characterized by a preoccupations with negative thoughts and by repetitive attempts to decrease or stop those behaviours. Two working hypotheses were tested to find neuromarkers of OCD and anxiety in the patient described. In agreement with the ‘OCD hypothesis’ an increase of the frontal beta activity and an increase of the parietalalpha activity pattern was found. The ‘anxiety’ hypothesis found confirmation in an increased left temporal P1 wave in response to the visual stimuli observed in ERPs. In all three conditions (EO, EC, GO/NOGO task), two characteristics were deviant from the normative average data in EEG spectra. First, an increase of frontal beta activity and the increase of parietal alpha activity was noted. The independent component analysis applied for 700 ms EEG fragments in GO and NOGO conditions revealed a strong activation over the central areas.
Conclusions:
pecific patterns of QEEG and ERPs, the increase of beta activity frontally, and the increase of parietal alpha activity pattern which produce hyper-frontality, might be useful in the diagnosis of an OCD patient. ERPs in a GO/NOGO task can be used in the assessment of functional brain changes in OCD patients.
REFERENCES (18)
1.
Diagnostic and statistical manual of mental disorders: DSM-5 (5 ed.). Washington: American Psychiatric Publishing. 2013. pp. 237–242.
2.
Fenske JN, Schwenk TL. Obsessive compulsive disorder: diagnosis and management”. Am Fam Physician. 2009; 80 (3): 239–45.
3.
Grant JE. Clinical practice: Obsessive-compulsive disorder”. N Eng J Med. 2014; 371 (7): 646–53.
4.
Goodman WK, Grice DE, Lapidus KA, Coffey BJ. Obsessive-compulsive disorder. Psychiatr Clin North Am. 2014; 37 (3): 257–67.
5.
Koran LM. Obsessive-Compulsive Disorder: An Update for the Clinician. Focus 2007;(5): 3.
6.
Abramowitz JS, Taylor S, McKay D.Obsessive-compulsive disorder. Lancet 2009; 374 (9688): 491–9.
7.
Kropotov JD. Quantitative EEG, event-related potentials and neurotherapy. Amsterdam, London: Elsevier Academic Press. 2009.
8.
Pąchalska M, Kaczmarek BLJ, Kropotov JD. Neuropsychologia kliniczna: od teorii do praktyki. Warszawa: Wydawnictwo Naukowe PWN. 2014.
9.
Shin NY, Lee TY, Kim E, Kwon JS. Cognitive functioning in obsessive-compulsive disorder: a meta-analysis. Psychol Med. 2013; 44: 1–10.
10.
Kolb B, Whishaw I. Fundamentals of human neuropsychology. 6 th Ed., New York: Worth Publishers. 2007.
11.
Kropotov JD. Functional neuromarkers for psychiatry. Elsevier Academic Press. 2016.
12.
Góral-Półrola J, Żychowska M, Ziółkowski A., Pąchalska M. Changes and expression of selected genes associated with cell stress in chronic stuttering: Case study. Acta Neuropsychol. 2015; 13(4): 390–401.
13.
Pachalska M, Góral-Półrola J, Brown JW, MacQueen BD.Consciousness and reality: a neuropsychological perspective. Acta Neuropsychol. 2015; 13(3): 205–227.
14.
Menzies L, Achard S, Chamberlain SR, Fineberg N, Chen CH, del Campo N, Sahakian BJ, Robbins TW, Bullmore E. Neurocognitive endophenotypes of obsessive-compulsive disorder. Brain. 2007; 130 (Pt 12): 3223–36.
15.
Starcevic V, Janca A. Obsessive-compulsive spectrum disorders: still in search of the concept-affirming boundaries. Current opinion in psychiatry. 2011; 24 (1): 55–60.
16.
Kropotov J D, Ponomarev V A, Kropotova O V, Anichkov A D, Nechaev V B. Human auditory-cortex mechanisms of preattentive sound discrimination. Neurosci Lett. 2000; 280: 87–90.
17.
Markarian Y, Larson MJ, Aldea MA, Baldwin SA, Good D, Berkeljon A, Murphy TK, Storch EA, McKay D. Multiple pathways to functional impairment in obsessive-compulsive disorder”.Clin Psychol Rev. 2010; 30 (1): 78–88.
18.
Mirski A, Pąchalska M, Moskała M, Orski M, Orska M, Miąskiewicz M, Zapała J, Kropotov JD. Neuromarkers of anxiety and depression in a patient after neuro-ophthalmic surgery of the meningioma – effect of individually-tailored tDCS and neurofeedback. Ann Agric Environ Med. 2015; 22(4): 730–735.
| eISSN: | 1898-2263 |
| ISSN: | 1232-1966 |
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