Online first
Current issue
Archive
Special Issues
About the Journal
Publication Ethics
Anti-Plagiarism system
Instructions for Authors
Instructions for Reviewers
Editorial Board
Editorial Office
Contact
Reviewers
All Reviewers
2023
2022
2021
2020
2019
2018
2017
2016
General Data Protection Regulation (RODO)
RESEARCH PAPER
Human toxocariasis seroprevalence among patients with uveitis in Alborz Province, Iran
1
Department of Parasitology and Mycology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
2
Evidence-based Phytotherapy & Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran
3
National Scientific and Technical Research Council, Research Institute on Animal Production, Department of Parasitology and Parasitic Diseases, Faculty of Veterinary Science, Buenos Aires, Argentina
4
Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
Ann Agric Environ Med. 2019;26(1):154-158
KEYWORDS
TOPICS
Exposure to physical hazards associated with the use of machinery in agriculture and forestry: noise, vibration, dustState of the health of rural communities depending on various factors: social factors, accessibility of medical care, etc.
ABSTRACT
Introduction and objective:
Toxocariasis, predominantly caused by Toxocara canis, is a common zoonotic parasitosis worldwide. Toxocara infection is a cause of vision impairment and blindness. The presented study investigates the frequency of antibodies against Toxocara among uveitis patients and the epidemiological factors associated with disease.
Material and methods:
Fifty-four patients with uveitis and 59 healthy subjects were studied. Anti-Toxocara antibodies status was determined in all serum samples using enzyme linked immunosorbent assay (ELISA), and seropositive samples analyzed by Western blot (WB) technique.
Results:
The frequency of Toxocara canis infection was found to be significantly higher in uveitis patients, compared to healthy controls by the use of ELISA test, being 14.8% and 1.7%, respectively. From 8 seropositive samples, 5 (62.5%) patients exhibited Toxocara immunoglobulin G (IgG) antibodies in response to Western blot, whereas in the control group, none were detected positive by Western blot. No significant difference was found between pet owners, nor between different places of residence. The seroprevalence to Toxocara among uveitis patients was significantly related to gender, age and medical diagnosis. The highest prevalence was found in patients with posterior uveitis (27.8%).
Conclusions:
Anti-Toxocara antibody titers are associated with the risk of vision impairment -uveitis. The risk factor associated with Toxocara exposure identified in this study warrants further investigation.
Toxocariasis, predominantly caused by Toxocara canis, is a common zoonotic parasitosis worldwide. Toxocara infection is a cause of vision impairment and blindness. The presented study investigates the frequency of antibodies against Toxocara among uveitis patients and the epidemiological factors associated with disease.
Material and methods:
Fifty-four patients with uveitis and 59 healthy subjects were studied. Anti-Toxocara antibodies status was determined in all serum samples using enzyme linked immunosorbent assay (ELISA), and seropositive samples analyzed by Western blot (WB) technique.
Results:
The frequency of Toxocara canis infection was found to be significantly higher in uveitis patients, compared to healthy controls by the use of ELISA test, being 14.8% and 1.7%, respectively. From 8 seropositive samples, 5 (62.5%) patients exhibited Toxocara immunoglobulin G (IgG) antibodies in response to Western blot, whereas in the control group, none were detected positive by Western blot. No significant difference was found between pet owners, nor between different places of residence. The seroprevalence to Toxocara among uveitis patients was significantly related to gender, age and medical diagnosis. The highest prevalence was found in patients with posterior uveitis (27.8%).
Conclusions:
Anti-Toxocara antibody titers are associated with the risk of vision impairment -uveitis. The risk factor associated with Toxocara exposure identified in this study warrants further investigation.
REFERENCES (28)
1.
Despommier D. Toxocariasis: clinical aspects, epidemiology, medical ecology, and molecular aspects. Clinical Microbiol Rev. 2003; 16: 265–272.
2.
Maraghi S, Jafari KM, Sadjjadi SM, Latifi SM, Zibaei M. Study on the contamination of Abadan public parks soil with Toxocara spp. eggs. J Environ Health Sci Eng. 2014; 12: 86.
3.
Zibaei M, Sadjjadi SM, Maraghi S. The occurrence of Toxocara species in naturally infected broiler chickens revealed by molecular approaches. J Helminth. 2017; 91: 633–636.
4.
Błaszkowska J, Góralska K, Wójcik A, Kurnatowski P, Szwabe K. Presence of Toxocara spp. eggs in children’s recreation areas with varying degrees of access for animals. Ann Agric Environ Med. 2015; 22: 23–27.
5.
Borecka A, Kłapeć T. Epidemiology of human toxocariasis in Poland–A review of cases 1978–2009. Ann Agric Environ Med. 2015; 22: 28–31.
6.
Brown GC, Tasman WS. Retinal arterial obstruction in association with presumed Toxocara canis neuroretinitis. Ann Ophthalmol. 1981; 13: 1385–1387.
7.
Jee D, Kim KS, Lee WK, Kim W, Jeon S. Clinical features of ocular toxocariasis in adult Korean patients. Ocul Immunol Inflamm. 2015; 24: 207–216.
8.
Sabrosa NA, de Souza EC. Nematode infections of the eye: toxocariasis and diffuse unilateral subacute neuroretinitis. Curr Opin Ophthalmol. 2001; 12: 450–454.
9.
Ahn SJ, Ryoo NK, Woo SJ. Ocular toxocariasis: clinical features, diagnosis, treatment, and prevention. Asia Pac Allergy. 2014; 4: 134.
10.
Zibaei M, Sadjjadi SM, Jahadi-Hosseini SH. Toxocara cati larvae in the eye of a child: a case report. Asian Pac J Trop Biomed. 2014; 4: S53-S55.
11.
Goto H, Mochizuki M, Yamaki K, Kotake S, Usui M, Ohno S. Epidemiological survey of intraocular inflammation in Japan. Jap J Ophthalmol. 2007; 51: 41–44.
12.
Kwon JW, Sim Y, Jee D. Association between intermediate uveitis and toxocariasis in the Korean population. Medicine. 2017; 96: e5829.
13.
Zibaei M, Sadjjadi SM. Trend of toxocariasis in Iran: a review on human and animal dimensions. Iranian J Vet Res. 2017; 18: 233–242.
14.
Zibaei M, Bahadory M, Cardillo N, Khatami AR. Soil Contamination with eggs of Toxocara species in public parks of Karaj, Iran. Int J Enteric Pathog. 2017; 5: 45–48.
15.
Sánchez TJ, López GJ, González NM, Villaseca DE, Manieu MD, Roizen BA, et al. Prevalence of ocular lesions in children seropositive to Toxocara canis. Revista Chilena Infecto. 2011; 28: 431–434.
16.
Fan CK, Hung CC, Du WY, Liao CW, Su KE. Seroepidemiology of Toxocara canis infection among mountain aboriginal schoolchildren living in contaminated districts in eastern Taiwan. Trop Med Int Health. 2004; 9: 1312–1318.
17.
Stensvold CR, Skov J, Moller LN, Jensen PM, Kapel CM, Petersen E, et al. Seroprevalence of human toxocariasis in Denmark. Clin Vaccine Immunol. 2009; 16: 1372–1373.
18.
Fu CJ, Chuang TW, Lin HS, Wu CH, Liu YC, Langinlur MK, et al. Seroepidemiology of Toxocara canis infection among primary schoolchildren in the capital area of the Republic of the Marshall Islands. BMC Infect Dis. 2014; 14: 261.
19.
Zibaei M, Sadjjadi SM, Sarkari B, Uga S. Evaluation of Toxocara cati excretory–secretory larval antigens in serodiagnosis of human toxocariasis. J Clin Lab Anal. 2015; 30: 248–253.
20.
Einipour S, Jalusian F, Ramezani A, Abadi A, Hajialiani F, Zeinali S, et al. Toxocariasis antibody tittering in patients with uveitis. Koomesh. 2016; 17: 903–909.
21.
Sharkey JA, McKay PS. Ocular toxocariasis in a patient with repeatedly negative ELISA titre to Toxocara canis. Br J Ophthalmol. 1993; 77: 253–254.
22.
Altcheh J, Nallar M, Conca M, Biancardi M, Freilij H. Toxocariasis: clinical and laboratory features in 54 patients. An Pediatr (Barc). 2003; 58: 425–431.
23.
Hashida N, Nakai K, Nishida K. Diagnostic evaluation of ocular toxocariasis using high-penetration optical coherence tomography. Case Rep Ophthalmol. 2014; 5: 16–21.
24.
Pak KY, Park SW, Byon IS, Lee JE. Ocular toxocariasis presenting as bilateral scleritis with suspect retinal granuloma in the nerve fiber layer: a case report. BMC Infect Dis. 2016; 16: 426.
25.
Good B, Holland CV, Taylor MRH, Larragy J, Moriarty P, Regan MO. Ocular toxocariasis in schoolchildren. Clin Infect Dis. 2004; 39: 173–178.
26.
Chávez JPB, Díaz RH, Peña AH, Isaías RC, Yrma EB, Gonzalez WR, et al. Human toxocariosis in Peru: Aspects of epidemiology, clinical and laboratory. Acta Med Peruana. 2011; 28: 228–236.
27.
Yang HK, Woo SJ, Hwang JM. Toxocara optic neuropathy after ingestion of raw meat products. Optom Vis Sci. 2014; 91: e267–273.
28.
Wilkinson CP, Welch RB. Intraocular Toxocara. Am J Ophthalmol. 1971; 71: 921–930.
Share
RELATED ARTICLE
| eISSN: | 1898-2263 |
| ISSN: | 1232-1966 |
Improvement of visual identification of the journal - task financed under the agreement No. 618/P-DUN/2019 by the Minister of Science and Higher Education allocated to the activities of disseminating science.
Generation of the DOI (Digital Object Identifier) - task financed under the agreement No. 618/P-DUN/2019 by the Minister of Science and Higher
© 2006-2024 Journal hosting platform by Bentus
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
