Online first
Current issue
Archive
Special Issues
About the Journal
Publication Ethics
Anti-Plagiarism system
Instructions for Authors
Instructions for Reviewers
Editorial Board
Editorial Office
Contact
Reviewers
All Reviewers
2023
2022
2021
2020
2019
2018
2017
2016
General Data Protection Regulation (RODO)
RESEARCH PAPER
Evaluation of trace metals in follicular fluid in ICSI-treated patients
1
Diagnostic Techniques Unit, Faculty of Health Sciences, Medical University, Lublin, Poland
2
International Scientific Association for the Support and Development of Medical Technologies, Lublin, Poland
3
Department for Woman Health, Institute of Rural Health in Lublin, Poland
Corresponding author
Artur Wdowiak
Diagnostic Techniques Unit, Faculty of Health Sciences, Medical University, Lublin, Poland
Diagnostic Techniques Unit, Faculty of Health Sciences, Medical University, Lublin, Poland
Ann Agric Environ Med. 2018;25(2):213-218
KEYWORDS
trace metalsintracytoplasmic sperm injection (ICSI)embryo development dynamicstime-lapse monitoringfollicular fluid
ABSTRACT
This study investigated the influence of cadmium (Cd), copper (Cu), iron (Fe), lead (Pb), selenium (Se), and zinc (Zn) in follicular fluid on the effectiveness of in vitro fertilization (IVF) treatment and the dynamics of embryo development. The study involved 221 women aged 25–35 years in whom intracytoplasmic sperm injection (ICSI) was performed. Analysis of the effects of the average concentrations of Se, Zn, and Cu on the evelopmental dynamics of embryos showed that higher concentrations of these metals were accompanied by shorter lead times for each of the various stages of development, while the reverse was true in the case of cadmium and lead. No relationship was observed between the mean concentrations of Fe and the dynamics of the human embryo. In order to discover whether the fact of becoming pregnant is affected by the investigated variables, a logistic regression model was applied. The dependent variable was the fact of achieving pregnancy, and the independent variable tested was the level of trace metals. Ultimately, only one variable remained statistically significant
in the model: the level of Se.
REFERENCES (36)
1.
Wdowiak A, Wdowiak A, Moroz E, Bojar I. Comparison of selected sperm parameters between 6,278 males in Poland and Ukraine. Ann Agric Environ Med. 2016; 23: 174–81 https://doi.org/10.5604/123219....
2.
Carlsen E, Giwercman A, Keiding N, Skakkebaek NE. Evidence for decreasing quality of semen during past 50 years. BMJ 1992; 305: 609–13 https://www.ncbi.nlm.nih.gov/p....
3.
Rzymski P, Tomczyk K, Rzymski P, Poniedziałek B, Opala T, Wilczak M. Impact of heavy metals on the female reproductive system. Ann Agric Environ Med. 2015; 22: 259–64 https://doi.org/10.5604/123219....
4.
Polańska K, Hanke W, Sobala W, Trzcinka-Ochocka M, Ligocka D, Strugała-Stawik H, Magnus P. Predictors of environmental lead exposure among pregnant women: A prospective cohort study in Poland. Ann Agric Environ Med. 2014; 21: 49–54 http://www.aaem.pl/pdf-72057-9....
5.
Marzec Z, Koch W, Marzec A, Żukiewicz-Sobczak W. Dietary exposure to cadmium, lead and nickel among students from south-east Poland. Ann Agric Environ Med. 2014; 21: 825–8 https://doi.org/10.5604/123219....
6.
Agarwal A, Aponte-Mellado A, Premkumar BJ, Shaman A, Gupta S. The effects of oxidative stress on female reproduction: A review. Reprod Biol Endocrinol. 2012 ; 10, 49. https://doi.org/10.1186/1477-7....
7.
Wdowiak A, Wdowiak A. Comparing antioxidant enzyme levels in follicular fluid in ICSI-treated patients (Comparaison des taux d’antioxydants enzymatiques dans le liquid folliculaire de patients prises en charge en ICSI). Gynecol Obstet Fertil. 2015; 43: 515–521 http://dx.doi.org/10.1016/j.gy....
8.
Kurus M, Karakaya C, Karalok MH, To G, Johnson J. The control of oocyte survival by intrinsic and extrinsic factors. AdvExp Med Biol. 2013; 761: 7–18 https://doi.org/10.1007/978-1-....
9.
Kumar S, Mishra VV. Review: Toxins in reproductive fluid and in vitro fertilization (IVF) outcome. Toxicol Ind Health 2010; Sep; 26: 505–11 https://doi.org/10.1177/074823....
10.
Taha EA, Sayed SK, Ghandour NM, Mahran AM, Saleh MA, Amin MM, Shamloul R. Correlation between seminal lead and cadmium and seminal parameters in idiopathic oligoasthenozoospermic males. Cent European J Urol. 2013; 66: 84–92 https://doi.org/10.5173/ceju.2....
11.
Wirth JJ, Mijal RS. Adverse effects of low level heavy metal exposure on male reproductive function. Syst Biol Reprod Med. 2010; 56: 147–167 http://dx.doi.org/10.3109/1939....
12.
Sharma B, Singh S, Siddiqi NJ. Biomedical implications of heavy metals induced imbalances in redox systems. Biomed Res Int. 2014; 2014: 640754 https://doi.org/10.1155/2014/6....
13.
Ercal N, Gurer-Orhan H, Aykin-Burns N. Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage. Cur Top Med Chem. 2001; 1: 529–39.
14.
Espín S, Martínez-López E, Jiménez P, María-Mojica P, García-Fernández AJ. Effects of heavy metals on biomarkers for oxidative stress in Griffon vulture (Gyps fulvus). Environ Res. 2014; 129: 59–68 https://doi.org/10.1016/j.envr....
15.
Bozek U, Kłapeć T. Correlation between biological agents and levels of heavy metals in municipal sewage sludge. Ann Agric Environ Med. 2008; 15: 295–9.
16.
Wdowiak A, Bakalczuk G, Bakalczuk S. Evaluation of effect of selected trace elements on dynamics of sperm DNA fragmentation. Postepy Hig Med Dosw. 2015; 69: 1405–1410 http://europepmc.org/abstract/....
17.
Lieu PT, Heiskala M, Peterson PA, Yang Y. The roles of iron in health and disease. Mol Asp Med. 2001; 22:1–87 https://doi.org/10.1016/S0098-....
18.
Tong WH, Rouault TA. Metabolic regulation of citrate and iron by aconitases: role of iron-sulfur cluster biogenesis. Biometals 2007; 20: 549–64 https://doi.org/10.1007/s10534....
19.
Stamler JS. Redox signaling: nitrosylation and related target interactions of nitric oxide. Cell 1994; 78: 931–6. https://doi.org/10.1016/0092-8....
20.
Wdowiak A, Wdowiak A, Stec M, Stec M, Studzińska M. Time-lapse embryo imaging as a new approach to the embryo selection. Eur J Med Technol. 2014; 1: 22–28 http://www.medical-technologie....
21.
Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum. Reprod 2011; 26: 1270–83 https://doi.org/10.1093/humrep....
22.
Ceko MJ, Hummitzsch K, Hatzirodos N, Bonner WM, Aitken JB, Russell DL, Lane M, Rodgers RJ, Harris HH. X-Ray fluorescence imaging and other analyses identify selenium and GPX1 as important in female reproductive function. Metallomics. 2015; 7: 71–82 https://doi.org/10.1039/c4mt90....
23.
Singh AK, Chattopadhyay R, Chakravarty B, Chaudhury K. Markers of oxidative stress in follicular fluid of women with endometriosis and tubal infertility undergoing IVF. Reprod Toxicol. 2013; 42: 116–24 https://doi.org/10.1016/j.repr....
24.
Paszkowski T, Traub AI, Robinson SY, McMaster D. Selenium dependent glutathione peroxidase activity in human follicular fluid. Clin Chim Acta 1995; 236: 173–80 https://doi.org/10.1016/0009-8....
25.
Borowiecka M, Wojsiat J, Polac I, Radwan M, Radwan P, Zbikowska HM. Oxidative stress markers in follicular fluid of women undergoing in vitro fertilization and embryo transfer. Syst Biol Reprod Med. 2012; 58: 301–5 https://doi.org/10.3109/193963....
26.
Bedaiwy MA, Elnashar SA, Goldberg JM, Sharma R, Mascha EJ, Arrigain S, et al. Effect of follicular fluid oxidative stress parameters on intracytoplasmic sperm injection outcome. Gynecol Endocrinol. 2012; 28: 51–5 https://doi.org/10.3109/095135....
27.
Wdowiak A, Lewicka M, Plewka K, Bakalczuk G. Nicotinism and quality of embryos obtained in in-vitro fertilization programmes. Ann Agric Environ Med. 2013; 20: 82–5 http://aaem.pl/fulltxt.php?ICI....
28.
Al-Saleh I, Coskun S, Mashhour A, Shinwari N, El-Doush I, Billedo G, et al. Exposure to heavy metals (lead, cadmium and mercury) and its effect on the outcome of in-vitro fertilization treatment. Int J Hyg Environ Health 2008; 211: 560–79 https://doi.org/10.1016/j.ijhe....
29.
Jorssen EP, Vergauwen L, Goossens K, Hagenaars A, Van Poucke M, Petro E, Peelman L, Knapen D, Leroy JL, Bols PE. Optimisation of the bovine whole in vitro embryo system as a sentinel for toxicity screening: a cadmium challenge. Altern Lab Anim. 2015; 43: 89–100 https://www.ncbi.nlm.nih.gov/p....
30.
Butts CD, Bloom MS, Frye CA, Walf AA, Parsons PJ, Steuerwald AJ, Ilonze C, Fujimoto VY. Urine cortisol concentration as a biomarker of stress is unrelated to IVF outcomes in women and men. J Assist Reprod Genet. 2014; 31: 1647–53 https://doi.org/10.1007/s10815....
31.
Pfeiffer MJ, Taher L, Drexler H, Suzuki Y, Makałowski W, Schwarzer C, Wang B, Fuellen G, Boiani M. Differences in embryo quality are associated with differences in oocyte composition: a proteomic study in inbred mice. Proteomics. 2015; 15: 675–87 https://doi.org/10.1002/pmic.2....
32.
Jomova K, Valko M. Importance of iron chelation in free-radical-induced oxidative stress and human disease. Curr Pharm Des. 2011; 17: 3460–3473 https://doi.org/10.2174/138161....
33.
Sanchez AM, Papaleo E, Corti L, Santambrogio P, Levi S, Viganň P, Candiani M, Panina-Bordignon P. Iron availability is increased in individual human ovarian follicles in close proximity to an endometrioma compared with distal ones. Hum Reprod. 2014; Mar 29: 577–83 https://doi.org/10.1093/humrep....
34.
Daughtry BL, Chavez SL. Chromosomal instability in mammalian pre-implantation embryos: potential causes, detection methods, and clinical consequences. Cell Tissue Res. 2016; 363: 201–25. http://dx.doi.org/10.1007/s004....
35.
Hanna CW, Bloom MS, Robinson WP, Kim D, Parsons PJ, vomSaal FS, Taylor JA, Steuerwald AJ, Fujimoto VY. DNA methylation changes in whole blood is associated with exposure to the environmental contaminants, mercury, lead, cadmium and bisphenol A, in women undergoing ovarian stimulation for IVF. Hum Reprod. 2012; 27: 1401–10. https://doi.org/10.1093/humrep....
36.
Wdowiak A. Sperm epigenetic profile and risk of cancer. J Pre-Clin Clin Res. 2012; 8: 67–70 http://www.jpccr.eu/Sperm-epig....
| eISSN: | 1898-2263 |
| ISSN: | 1232-1966 |
Improvement of visual identification of the journal - task financed under the agreement No. 618/P-DUN/2019 by the Minister of Science and Higher Education allocated to the activities of disseminating science.
Generation of the DOI (Digital Object Identifier) - task financed under the agreement No. 618/P-DUN/2019 by the Minister of Science and Higher
© 2006-2024 Journal hosting platform by Bentus
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
