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2/2020 vol. 27
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RESEARCH PAPER
Epilepsy in paediatric patients with schizencephaly
Ilona Kopyta 1
,
 
Michał Skrzypek 2
,
 
Dorota Raczkiewicz 3
,
 
Iwona Bojar 4
,
 
Beata Sarecka-Hujar 5
 
 
 
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1
Department of Paediatric Neurology, School of Medicine, Medical University of Silesia, Katowice, Poland
 
2
Department of Biostatistics, School of Public Health in Bytom, Medical University of Silesia, Katowice, Poland
 
3
Institute of Statistics and Demography, School of Economic Warsaw, Poland
 
4
Department of Women’s Health, Institute of Rural Health, Lublin, Poland
 
5
Department of Basic Biomedical Science, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland
 
 
Corresponding author
Beata Sarecka-Hujar   

Department of Basic Biomedical Science, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice
 
 
Ann Agric Environ Med. 2020;27(2):279-283
DOI: https://doi.org/10.26444/aaem/122796
 
 
Article (PDF)
References (26)
 
KEYWORDS
schizencephaly
bilateral
unilateral
central nervous system malformation
Epilepsy
developmental delay
 
TOPICS
State of the health of rural communities depending on various factors: social factors, accessibility of medical care, etc.
 
ABSTRACT
Introduction:
Schizencephaly is one of the rare congenital defects of the central nervous system (CNS), known as neuronal migration disorders. The etiology of schizencecephaly is unequivocal. Established etiologies include in-utero infections (cytomegalovirus and herpes simplex virus, HSV type I), toxic abuse (cocaine, alcohol), as well as drug use (warfarin).

Objectives:
he aim of the study was to analyze the clinical presentation of schizencephaly with particular consideration of the course of epilepsy in paediatric patients.

Material and methods:
The study group consisted of 38 children with schizencephaly (20 of them had seizure) and was retrospectively assessed. Data were analyzed using SAS version 9.4. U Mann-Whitney and χ 2 tests and logistic regression analysis were used in statistical analyses.

Results:
Epilepsy was the most frequent in bilateral type II schizencephaly (p=0.033). In logistic regression analysis, the presence of bilateral open schizencephaly significantly increased the risk of seizures (OR=11.67; 95%CI 2.44–55.83; p=0.002). Drug-resistant epilepsy was observed in 9 children (45% of the children with epilepsy). Prevalence of both epilepsy and drug-resistant epilepsy in schizencephaly did not significantly depend on gender, stage of development, type or localization of schizencephaly, and other coexisting CNS defects or clinical presentation of schizencephaly at follow-up in the study group of patients.

Conclusions:
The bilateral type of schizencephaly was identified as an independent risk factor for epilepsy in the analyzed children.

 
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