CASE REPORT
Mycobacterium caprae tuberculosis in a captive lion in Ukraine – Case Report
1
Department of Food Hygiene and Public Health Protection, Institute of Veterinary Medicine, University of Life Sciences, Warsaw, Poland
2
Sub-Department of Microbiology, Department of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland
3
Department of Science and Technology, National Research Foundation Centre of Excellence for Biomedical TB Research, South African Medical Research Council Centre for Tuberculosis Research, Cape Town, South Africa
4
Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa
5
Department of Microbiology, National Tuberculosis and Lung Diseases Research Institute, Puławy, Poland
6
Department of Microbiology, National Veterinary Research Institute, Puławy, Poland
7
Pope John Paul II State School of Higher Education, Biała Podlaska, Poland
These authors had equal contribution to this work
Corresponding author
Monika Krajewska-Wędzina
Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Institute of Preclinical Veterinary Sciences, University of Life Sciences, Lublin, Poland, Poland
Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Institute of Preclinical Veterinary Sciences, University of Life Sciences, Lublin, Poland, Poland
KEYWORDS
TOPICS
ABSTRACT
Introduction and Objective. Because of the armed conflict in Ukraine, companion, farm and captive wild animals have been moved in a simplified procedure across the Polish-Ukrainian border. For that reason, in 2022, Poznań Zoo provided support for almost 200 wild animals before movement to facilities in other countries. The aim of the study is to identify the under-recognized risk of moving animals that may be infected with zoonotic pathogens, such as Mycobacterium caprae, between countries.
Materials and Method. Sections of the heart, lungs, and mesentery of 4-year-old lioness from Ukraine were taken for histopathological and bacteriological examination.
Results. Microbiological examinations confirmed the presence of Mycobacterium caprae, SB0418 spoligotype.
Conclusion. TB is a zoonotic disease present globally. Movement of captive wild animals from regions with MTBC cases, or lack of MTBC surveillance, such as UA may pose a potential threat to public health.
ACKNOWLEDGEMENTS
This work would not have been possible without the
cooperation Jarosław Przybylski, the veterinarian at Poznań
Zoo.
REFERENCES (37)
1.
Haque U, Naeem A, Wang S, Espinoza J, Holovanova I, Gutor T, et al. The human toll and humanitarian crisis of the Russia-Ukraine war: the first 162 days. BMJ Glob Health. 2022;7(9):e009550. doi:10.1136/bmjgh-2022-009550.
2.
UNHCR;the UN Refugee Agency, 2022. Ukraine situation: Flash Update #15, 2022, online available: https://data.unhcr.org/en/docu... [Accessed June 28 2022].
4.
Krajewska-Wędzina M, Miller MA, Didkowska A, Kycko A, Radulski Ł, Lipiec M, Weiner M. The Potential Risk of International Spread of Mycobacterium Bovis Associated with Movement of Alpacas. J Vet Res. 2022;66(1):53–59. doi:10.2478/jvetres-2022-0012.
5.
Wolner ZJ, Mustin DE, Stoff BK. Preordering Periodic Acid-Schiff Staining: A Quality Improvement Study. Am J Dermatopathol. 2023;45(12):825–827. doi:10.1097/DAD.0000000000002570.
6.
Krajewska M. Characterization of Mycobacterium bovis strains isolated from animals in Poland (in Polish). PhD thesis. Pulawy, Poland: National Veterinary Research Institute; 2015.
7.
Kandhakumari G, Stephen S. Evaluation of a new rapid kit, BD MGIT TBc identification test for confirmation of Mycobacterium tuberculosis complex. Indian J Pathol Microbiol. 2017;60(2):243–246. doi:10.4103/IJPM.IJPM_695_15.
8.
Orłowska B, Majchrzak M, Didkowska A, Anusz K, Krajewska-Wędzina M, et al. Mycobacterial Interspersed Repeat Unit-Variable Number Tandem Repeat Typing of Mycobacterium avium Strains Isolated from the Lymph Nodes of Free-Living Carnivorous Animals in Poland. Pathogens. 2023;12(9):1184. doi:10.3390/pathogens12091184.
9.
Couvin D, David A, Zozio T, Rastogi N. Macro-geographical specificities of the prevailing tuberculosis epidemic as seen through SITVIT2, an updated version of the Mycobacterium tuberculosis genotyping database. Infect Genet Evol. 2019;72:31–43. doi:10.1016/j.meegid.2018.12.030.
10.
Hu Y, Wu X, Luo J, Fu Y, Zhao L, Ma Y, et al. Detection of pyrazinamide resistance of Mycobacterium tuberculosis using nicotinamide as a surrogate. Clin Microbiol Infect. 2017 Nov;23(11):835–838. doi:10.1016/j.cmi.2017.03.028.
11.
World Health Organization, 2023. Global tuberculosis report 2023. Geneva, Switzerland.
12.
Pavlenko E, Barbova A, Hovhannesyan A, Tsenilova Z, Slavuckij A, Shcherbak-Verlan B, et al. Alarming levels of multidrug-resistant tuberculosis in Ukraine: results from the first national survey. Int J Tuberc Lung Dis. 2018;22(2):197–205. doi:10.5588/ijtld.17.0254.
13.
Butov D, Lange C, Heyckendorf J, Kalmykova I, Butova T, Borovok N, et al. Multidrug-resistant tuberculosis in the Kharkiv Region, Ukraine. Int J Tuberc Lung Dis. 2020;24(5):485–491. doi:10.5588/ijtld.19.0508.
14.
Kassich I, Kochmarskiĭ VA, Zavgorodniĭ AI, Borziak AT, Korotchenko NV, Manchenko VM, et al. Vzaimosviaz’ tuberkuleza krupnogo rogatogo skota i liudeĭ [The interrelation of bovine and human tuberculosis]. Probl Tuberk. 1990;(6):23–6. [in Russian].
15.
Mitchell JL, Gunn-Moore DA. Mycobacterial infections in dogs and cats. Vet Nurs J. 2019;34:102–107.
16.
Rocha VCF, Figueiredo SC, Rosales CAR, Porto CD, Sequeira JL, Neto JSF, et al. Infection by Mycobacterium bovis in a dog from Brazil. Braz J Microbiol. 2017;48:109–112.
17.
Neila C, Rebollada-Merino A, Bezos J, de Juan L, Domínguez L, Rodríguez-Bertos A. Extracellular matrix proteins (fibronectin, collagen III, and collagen I) immunoexpression in goat tuberculous granulomas (Mycobacterium caprae). Vet Res Commun. 2022;46(4):1147–1156. doi:10.1007/s11259-022-09996-3.
18.
Infantes-Lorenzo JA, Romero B, Rodríguez-Bertos A, Roy A, Ortega J, de Juan L, et al. Tuberculosis caused by Mycobacterium caprae in a camel (Camelus dromedarius). BMC Vet Res. 2020;16(1):435. doi:10.1186/s12917-020-02665-0.
19.
Yoshida S, Suga S, Ishikawa S, Mukai Y, Tsuyuguchi K, Inoue Y, et al. Mycobacterium caprae Infection in Captive Borneo Elephant, Japan. Emerg Infect Dis. 2018;24(10):1937–1940. doi:10.3201/eid2410.180018.
20.
Krajewska-Wędzina M, Kozińska M, Orłowska B, Weiner M, Szulowski K, Augustynowicz-Kopeć E, et al. Molecular characterisation of Mycobacterium caprae strains isolated in Poland. Vet Rec. 2018;182(10):292. doi:10.1136/vr.104363.
21.
Orłowska B, Krajewska-Wędzina M, Augustynowicz-Kopeć E, Kozińska M, Brzezińska S, Zabost A, et al. Epidemiological characterization of Mycobacterium caprae strains isolated from wildlife in the Bieszczady Mountains, on the border of Southeast Poland. BMC Vet Res. 2020;16(1):362. doi:10.1186/s12917-020-02581-3.
22.
Cöllü AY, Ucarman N, Bayhan GI. Complicated clinical course of zoonotic tuberculosis due to Mycobacterium Caprae: A case report and literature review. Int J Mycobacteriol. 2022;11(4):466–468. doi:10.4103/ijmy.ijmy_148_22.
23.
Martínez-Lirola M, Herranz M, Buenestado Serrano S, Rodríguez-Grande C, Dominguez Inarra E, Garrido-Cárdenas JA, et al. A One Health approach revealed the long-term role of Mycobacterium caprae as the hidden cause of human tuberculosis in a region of Spain, 2003 to 2022. Euro Surveill. 2023;28(12):2200852. doi:10.2807/1560-7917.ES.2023.28.12.2200852.
25.
Kozińska M, Krajewska-Wędzina M, Augustynowicz-Kopeć E. Mycobacterium caprae – the first case of the human infection in Poland. Ann Agric Environ Med. 2020;27(1):151–153. doi:10.26444/aaem/108442.
26.
Papaventsis D, Dougas G, Kalkouni O, Karabela S, Manika K. Occupational Exposure to Zoonotic Tuberculosis Caused by Mycobacterium caprae, Northern Greece, 2019. Emerg Infect Dis. 2021;27(7):1997–1999. doi:10.3201/eid2707.204399.
27.
Lamine-Khemiri H, Martínez R, García-Jiménez WL, Benítez-Medina JM, Cortés M, Hurtado I, et al. Genotypic characterization by spoligotyping and VNTR typing of Mycobacterium bovis and Mycobacterium caprae isolates from cattle of Tunisia. Trop Anim Health Prod. 2014;46(2):305–11. doi:10.1007/s11250-013-0488-y.
28.
Ghielmetti G, Scherrer S, Friedel U, Frei D, Suter D, Perler L, et al. Epidemiological tracing of bovine tuberculosis in Switzerland, multilocus variable number of tandem repeat analysis of Mycobacterium bovis and Mycobacterium caprae. PLoS One. 2017;12(2):e0172474. doi:10.1371/journal.pone.0172474.
29.
Magnani R, Cavalca M, Pierantoni M, Luppi A, Cantoni AM, Prosperi A, et al. Infection by Mycobacterium caprae in three cattle herds in Emilia-Romagna Region, Northern Italy. Ital J Food Saf. 2020;9(1):8467. doi:10.4081/ijfs.2020.8467.
30.
Eulenberger K, Elze K, Schüppel KF, Seifert S, Ippen R, Schroder HD. Tuberkulose und ihre bekämpfung bei primaten un feliden im Leipziger Zoologischen Garten von 1951–1990. Sandtander, Spain. 1992:7–15.
31.
Viljoen IM, van Helden PD, Millar RP. Mycobacterium bovis infection in the lion (Panthera leo): Current knowledge, conundrums and research challenges. Vet Microbiol. 2015;177(3–4):252–260. doi:10.1016/j.vetmic.2015.03.028.
32.
Dippenaar A, Parsons SDC, Miller MA, Hlokwe T, Gey van Pittius NC, Adroub SA, et al. Progenitor strain introduction of Mycobacterium bovis at the wildlife-livestock interface can lead to clonal expansion of the disease in a single ecosystem. Infect Genet Evol. 2017;51:235–238. doi: 10.1016/j.meegid.2017.04.012.
33.
Kapustin N, Ball R, Teare JA, Greenwald R, Esfandiari J, Lyashchenko K. Tuberculosis diagnosis in jaguar (Panthera onca onca) and addra gazelle (Gazella dama ruficollis) using multiple antigen print immunoassay and rapid lateral flow technology. In: Proceedings of the American Association of Zoo Veterinarians, Tampa, September 19–24, 2006. American Association of Zoo Veterinarians, White Oak, Florida. 2006:257–260.
34.
O’Halloran C, Tørnqvist-Johnsen C, Woods G, Mitchell J, Reed N, Burr P, et al. Feline tuberculosis caused by Mycobacterium bovis infection of domestic UK cats associated with feeding a commercial raw food diet. Transbound Emerg Dis. 2021;68(4), 2308–2320. doi:10.1111/tbed.13889.
35.
Prodinger WM, Brandstätter A, Naumann L, Pacciarini M, Kubica T, Boschiroli, ML, et al. Characterization of Mycobacterium caprae isolates from Europe by mycobacterial interspersed repetitive unit genotyping. J Clin Microbiol. 2005;43(10):4984–4992. doi:10.1128/JCM.43.10.4984-4992.2005.
36.
Bruczyńska M, Didkowska A, Michalski M, Brzezińska S, Augustynowicz-Kopeć E, Anusz K. Bovine tuberculosis in a Reeves’s muntjac (Muntiacus reevesi) in a private animal collection in Poland – management and legal implications. Ann Agric Environ Med. 2022;29(3):365–369. doi:10.26444/aaem/150007.
37.
Danišová O, Valenčáková A, Kandráčová P, Tomko M, Sučik M. First report of Blastocystis spp. subtypes in ZOO animals in Slovakia, Central Europe. Ann Agric Environ Med. 2022;29(1):149–151. doi:10.26444/aaem/145826.
Share
RELATED ARTICLE
| eISSN: | 1898-2263 |
| ISSN: | 1232-1966 |
Improvement of visual identification of the journal - task financed under the agreement No. 618/P-DUN/2019 by the Minister of Science and Higher Education allocated to the activities of disseminating science.
Generation of the DOI (Digital Object Identifier) - task financed under the agreement No. 618/P-DUN/2019 by the Minister of Science and Higher
© 2006-2024 Journal hosting platform by Bentus
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
