RESEARCH PAPER
Do polyomavirus hominis strains BK and JC play a role in oral squamous cell carcinoma?
1
Department of Virology, Medical University, Lublin, Poland
2
Department of Otolaryngology, Head, and Neck Surgery, Medical University, Lublin, Poland
Ann Agric Environ Med. 2015;22(1):106-109
KEYWORDS
ABSTRACT
Introduction:
Introduction. Head and neck cancers are the most common cancers worldwide. It is estimated that approximately 90% of all head and neck cancers are represented by squamous cell carcinoma (SCC). There are many risk factors causing this type of cancer, including environmental factors and lifestyle choices, such as tobacco smoking or abusing alcohol. Other important risk factor include infectious factors.
Objective:
The aim of this study was to analyze the prevalence of BK and JC virus infections among patients with oral squamous cell carcinoma (OSCC).
Material and Methods:
The correlation between BKV infection and OSCC, and correlation between BKV, OSCC, alcohol abuse, tobacco smoking, demographic data, pre-treatment staging, metastases of lymph node evidence, and grading, was analyzed. The study group consisted of 92 patients with squamous cell carcinoma (OSCC), 75 males, and 17 females, aged between 40 – 87 (average 56.8). All the patients underwent surgery and were not subjected to chemotherapy or radiotherapy prior to treatment. The analyzed samples were collected from paraffin sections.
Results:
BKV DNA was detected in 18.5% of patients with OSCC. In the control group, BKV DNA was detected in 3.3%. BKV DNA was statistically more frequently detected among patients with squamous carcinoma, compared to the control group (p<0.05).
Conclusions:
The obtained results suggest that the BKV virus may play an important role in the development of oral squamous cell carcinoma.
Introduction. Head and neck cancers are the most common cancers worldwide. It is estimated that approximately 90% of all head and neck cancers are represented by squamous cell carcinoma (SCC). There are many risk factors causing this type of cancer, including environmental factors and lifestyle choices, such as tobacco smoking or abusing alcohol. Other important risk factor include infectious factors.
Objective:
The aim of this study was to analyze the prevalence of BK and JC virus infections among patients with oral squamous cell carcinoma (OSCC).
Material and Methods:
The correlation between BKV infection and OSCC, and correlation between BKV, OSCC, alcohol abuse, tobacco smoking, demographic data, pre-treatment staging, metastases of lymph node evidence, and grading, was analyzed. The study group consisted of 92 patients with squamous cell carcinoma (OSCC), 75 males, and 17 females, aged between 40 – 87 (average 56.8). All the patients underwent surgery and were not subjected to chemotherapy or radiotherapy prior to treatment. The analyzed samples were collected from paraffin sections.
Results:
BKV DNA was detected in 18.5% of patients with OSCC. In the control group, BKV DNA was detected in 3.3%. BKV DNA was statistically more frequently detected among patients with squamous carcinoma, compared to the control group (p<0.05).
Conclusions:
The obtained results suggest that the BKV virus may play an important role in the development of oral squamous cell carcinoma.
REFERENCES (21)
1.
Bennett S, Broekema N, Imperiale M. BK polyomavirus: emerging pathogen. Microbes Infect. 2012; 14: 672–683.
2.
Neirynck V, Claes K, Naesens M, De Wever L, Pirenne J, Kuypers D, et al. Renal cell carcinoma in the allograft: what is the role of Polyomavirus? Case Rep Nephrol Urol. 2012; 2(2): 125–134.
3.
Schowalter R, Reinhold W, Buck C. Entry tropism of BK and Merkel cell polyomaviruses in cell culture. PLoS One. 2012; 7(7): 42181.
4.
Raeesi N, Gheissari A, Akrami M, Moghim S. Urinary BK virus excretion in children newly diagnosed with acute lymphoblastic leukemia. Int J Prev Med. 2012; 3(6): 402–407.
5.
Konietzny R, Fischer R, Ternette N, Wright C, Turney B, Chakera A, et al. Detection of BK virus in urine from renal transplant subjects my mass spectrometry. Clin Proteomics. 2012; 9(1): 4.
6.
Tognon M, Corallini A, Martini F, Negrini M, Barbanti-Brodano G. Oncogenic transformation by BK virus and association with human tumors. Oncogene 2003; 22: 5192–5200.
7.
Jeffers LK, Madden V, Webster-Cyriaque J. BK virus has tropism for human salivary gland cells in vitro: Implications for transmission. Virology 2009; 394: 183–193.
8.
Syrjanen S. Human papillomavirus (HPV) in head and neck cancer. J Clin Virol. 2005; 32(Suppl 1): 59–66.
9.
López RVM, Zago MA, Eluf-Neto J, Curado MP, Daudt AW, da Silva-Junior WA, et al. Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer Braz J Med Biol Res. 2011; 44(10): 1006–1012.
10.
Lambert R, Sauvaget C, de Camargo Cancela M, Sankaranarayanan R. Epidemiology of cancer from the oral cavity and oropharynx. Eur J Gastroenterol Hepatol. 2011; 23(8): 633–641.
11.
Rautava J, Kuuskoski J, Syrjänen K, Grenman R, Syrjänen S. HPV genotypes and their prognostic significance in head and neck squamous cell carcinomas. J Clin Virol. 2012; 53(2): 1116–12014.
12.
Podlodowska J, Szumiło J, Podlodowski W, Starosławska E, Burdan F. Epidemiology and risk factors of the oral carcinoma Pol Merkur Lekarski. 2012; 32(188): 135–137.
13.
Arthur RR, Dagostin S,Shah KV. Detection of BK virus and JC virus in urine and brain tissue by polymerase chain reaction. J Clin Microbiol. 1989; 27(6): 1174–1179.
14.
Cardesa A, Nadal A. Carcinoma of the head and neck in the HPV era. Acta Dermatovenerol Alp Panonica Adriat. 2011; 20(3): 161–173.
15.
Syrjänen K, Syrjänen S, Lamberg M, Pyrhönen S, Nuutinen J. Morphological and immunohistochemical evidence suggesting human papillomavirus involvement in oral squamous cell carcinogenesis. Int J Oral Surg, 1983;12: 418–424.
16.
Hachana M, Amara K, Ziadi S, Gacem RB, Korbi S, Trimeche M. Investigation of human JC and BK polyomaviruses in breast carcinomas Breast Cancer Res Treat. 2012; 133: 969–977.
17.
Naumnik B, Kowalewska J, Zalewski G, Charkiewicz R, Myśliwiec M. The status of BK polyomavirus replication in adult renal transplant recipients in northeastern Poland. Transplant Proc. 2011; 43(8): 2976–2984.
18.
Palmieri A, Carinci F, Martinelli M, Spinelli G, LoMuzio L, Rubini C, Scapoli L. Absence of simian virus 40, BK, and JC polyomavirus DNA in squamous cell carcinoma limited to the oral cavity. Head Neck. 2010; 32(3): 375–380.
19.
Fraase K, Hart J, Wu H, Pang X, Ma L, Grant F, et al. BK virus bas a potential co-factor for HPV in the development of cervical neoplasia. Ann Clin Lab Sci. 2011; 42(2): 130–134.
20.
Comar M, Bonifacio D, Zanconati F, Di Napoli M, Isidoro E, Martini F, et al. High prevalence of BK poliyomavirus sequences in Human papillomavirus-16-positive precancerous cervical lesions. J MedVirol. 2011; 83: 1770–1776.
21.
Golusiński W, Waśniewska E, Kaczmarek J, Kędzia D, Wróbal M, Malinowska B, Szyfter W. Patients under 45 years of age “Young Adults“with head and neck squamous cell carcinoma – retrospective, multivariable analysis – preliminary report. Otolaryngologia Pol. 2003; 2: 185–189.
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