RESEARCH PAPER
Seroprevalence of hepatitis A virus antibodies (anti-HAV) in adult inhabitants of Wielkopolska region, Poland – the role of simple demographic factors
 
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1
Department of Infectious Diseases, University of Medical Sciences, Poznan, Poland
 
2
Department of Infectious Diseases, Jozef Strus Multidisciplinary Municipal Hospital, Poznan, Poland
 
3
Department of Computer Science and Statistics, University of Medical Sciences, Poznan, Poland
 
 
Ann Agric Environ Med. 2012;19(4):738-741
 
KEYWORDS
ABSTRACT
Introduction and objective:
Based on the available epidemiologic data, Poland currently has the features typical for areas of very low endemicity for hepatitis A. The incidence of hepatitis A in the Wielkopolska region in years 2006-2008 was 0.68/100,000 inhabitants or significantly lower. The aim of this cross-sectional analysis was to evaluate the seroprevalence of anti-HAV antibodies in inhabitants of the Wielkopolska region of western Poland regarding some demographic factors.

Material and Methods:
In addition to testing anti-HAV antibodies, the medical history and demographic data, such as age, gender, place of residence, and level of education of 680 patients and 105 healthy blood donors were analyzed.

Results:
Anti-HAV antibodies were observed in 235 cases (29.9%). In univariate regression analysis, the covariates correlated with positive anti-HAV testing were age, female gender and lower level of education. Only 6.2% of young adults were seropositive. Among study participants above the age of 50, anti-HAV antibodies were present in 64-100% of cases. An icteric disease consistent with hepatitis A diagnosis was identified in the histories of 10.2% of seropositive patients.

Conclusions:
The risk for contracting disease after exposure to HAV in young (<40 years old) inhabitants of the Wielkopolska region is high. Apart from older individuals, also women and people with a lower level of education are more frequently seropositive. A low level of immunity to HAV should be an indication for vaccination against HAV , especially in selected groups.

 
REFERENCES (29)
1.
Pringle CR. Virus taxonomy at the XI th International Congress of Virology, Sydney, Australia, 1999. Arch Virol. 1999; 144(10): 2065-2070.
 
2.
Cuthbert JA. Hepatitis A: old and new. Clin Microbiol Rev. 2001; 14(1): 38-58.
 
3.
Koff RS. Hepatitis A. Lancet 1998; 351(9116): 1643-1649.
 
4.
Baumann A. Wirusowe zapalenie wątroby typu A w Polsce w latach 2006-2007 (Hepatitis A in Poland in the years 2006-2007). Przegl Epidemiol. 2009; 63(2): 241-244 (in Polish).
 
5.
Baumann A. Wirusowe zapalenie wątroby typu A w Polsce w 2008 roku (Hepatitis A in Poland in 2008). Przegl Epidemiol. 2010; 64(2): 235-237 (in Polish).
 
6.
Janaszek-Seydlitz W, Bucholc B, Wiatrzyk A. Poziom przeciwciał przeciwko wirusowemu zapaleniu wątroby typu A u osób z terenu Warszawy (Prevalence of anti-HAV antibodies in Warsaw population). Przegl Epidemiol. 2007; 61(4): 675-682 (in Polish).
 
7.
Cianciara J. Hepatits A shifting in Poland and Eastern Europe. Vaccine 2000; 18 (Suppl. 1): S68-S70.
 
8.
Meldunki o zachorowaniach na choroby zakaźne, zakażeniach i zatruciach w Polsce (Reports on morbidity of infectious diseases and poisonings in Poland) (in Polish). http://www.pzh.gov.pl/oldpage/... (access: 2011.03.03).
 
9.
Magdzik W, Czarkowski MP. Zmiany w endemiczności wirusowego zapalenia wątroby typu A (wzw A) w Polsce (Changes in endemicity at hepatitis A in Poland). Przegl Epidemiol. 2004; 58(1): 3-8 (in Polish).
 
10.
Cianciara J, Gładysz A, Juszczyk J, Drozdowicz A, Duszczyk E, Łoch T, et al. Próba oceny sytuacji epidemicznej zakażeń HAV w Polsce – wyniki badań przesiewowych anty-HAV klasy IgG (Epidemiology of hepatitis A in Poland – serological surveys). In: Juszczyk J (Ed): Hepatitis A Compendium, SmithKline Beecham Pharmacuticals, Warszawa 1997. p. 29-35 (in Polish).
 
11.
Polz-Dacewicz MA, Policzkiewicz P, Badach Z. Changing epidemiology of hepatitis A virus infection – a comparative study in Central Eastern Poland (1990-1999). Med Sci Monit. 2000; 6(5): 989-993.
 
12.
Chlabicz S, Grzeszczuk A. Przewlekłe zapalenie wątroby typu C a ryzyko zakażenia wirusem zapalenia wątroby typu A (Chronic hepatitis C and risk for hepatitis A infection). Przegl Epidemiol. 2001; 55(3): 281-286 (in Polish).
 
13.
Cooksley WG. What did we learn from the Shanghai hepatitis A epidemic? J Viral Hepat. 2000; 7 (Suppl. 1): 1-3.
 
14.
Frank C, Walter J, Muehlen M, Jansen A, van Treeck U, Hauri AM, et al. Major outbreak of hepatitis A associated with orange juice among tourists, Egypt, 2004. Emerg Infect Dis. 2007; 13(1): 156-158.
 
15.
Hutin YJ, Pool V, Cramer EH, Nainan OV, Weth J, Williams IT, et al. A multistate, foodborne outbreak of hepatitis A. N Engl J Med. 1999; 340(8): 595-602.
 
16.
Państwowa Inspekcja Sanitarna – Powiatowa Stacja Sanitarno-Epidemiologiczna w Gostyniu. Ocena stanu sanitarnego i sytuacja epidemiologiczna powiatu gostyńskiego w roku 2009 (State Sanitary Inspection – Gostyn Sanitary Inspectotate: Sanitary condition and epidemiological situation in Gostyn district in 2009) (in Polish). http://pssegostyn.pis.gov.pl/p... (access: 2011.03.03).
 
17.
Dagan R, Leventhal A, Anis E, Slater P, Ashur Y, Shouval D. Incidence of hepatitis A in Israel following universal immunization of toddlers. JAMA 2005; 294(2): 202-210.
 
18.
Vacchino MN. Incidence of Hepatitis A in Argentina a er vaccination. Viral Hepat. 2008; 15 (Suppl. 2): 47-50.
 
19.
Van Damme P, Banatvala J, Fay O, Iwarson S, McMahon B, Van Herck K, et al. Hepatitis A booster vaccination: is there a need? Lancet 2003; 362(9389): 1065-1071.
 
20.
Van Damme P, Van Herck K. A review of the long-term protection after hepatitis A and B vaccination. Travel Med Infect Dis. 2007; 5(2): 79-84.
 
21.
Victor JC, Monto AS, Surdina TY, Suleimenova SZ, Vaughan G, Nainan OV, et al. Hepatitis A vaccine versus immune globulin for postexposure prophylaxis. N Engl J Med. 2007; 357(17): 1685-1694.
 
22.
Havrix Adult – Charakterystyka Produktu Leczniczego (Havrix Adult – full prescribing information) (in Polish). http://www.gsk.com.pl/Download... (access: 2011.03.03).
 
23.
Komunikat Głównego Inspektora Sanitarnego z dnia 28 października 2010r. w sprawie Programu Szczepień Ochronnych na rok 2011 (załącznik) (Chief Sanitary Inspector announcement about National Vaccination Program 2011 [appendix]) (in Polish). http://www.pis.gov.pl/user les/ le/Departament%20Przeciwepidemiczny/szczepienia/PSO%20na%202011.pdf (access: 2011.03.03).
 
24.
Cotter SM, Sansom S, Long T, Koch E, Kellerman S, Smith F, et al. Outbreak of hepatitis A among men who have sex with men: implications for hepatitis A vaccination strategies. J Infect Dis. 2003; 187(8): 1235-1240.
 
25.
Mazick A, Howitz M, Rex S, Jensen IP, Weis N, Katzenstein TL, et al. Hepatitis A outbreak among MSM linked to casual sex and gay saunas in Copenhagen, Denmark. Euro Surveill. 2005; 10(5): 111-114.
 
26.
Staes CJ, Schlenker TL, Risk I, Cannon KG, Harris H, Pavia AT, et al. Sources of infection among persons with acute hepatitis A and no identified risk factors during a sustained community-wide outbreak. Pediatrics 2000; 106(4): e54.
 
27.
Almasio PL, Amoroso P. HAV infection in chronic liver disease: a rationale for Vaccination. Vaccine 2003; 21(19-20): 2238-2241.
 
28.
Kee e EB. Is hepatitis A more severe in patients with chronic hepatitis B and other chronic liver diseases? Am J Gastroenterol. 1995; 90(2): 201-205.
 
29.
Vento S, Garofano T, Renzini C, Cainelli F, Casali F, Ghironzi G, et al. Fulminant hepatitis associated with hepatitis A virus superinfection in patients with chronic hepatitis C. N Engl J Med. 1998; 338(5): 286-290.
 
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