Two generation reproductive and developmental toxicity following subchronic exposure of pubescent male mice to di(2-ethylhexyl)phthalate

Małgorzata M. Dobrzyńska 1, Ewa J. Tyrkiel 2, Edyta Derezińska 1, Krzysztof A. Pachocki 1, Jan K. Ludwicki 2
1 - 1 Department of Radiation Protection and Radiobiology, National Institute of Public Health - National Institute of Hygiene, Warsaw, Poland
2 - 2 Department of Environmental Toxicology, National Institute of Public Health - National Institute of Hygiene, Warsaw, Poland
Ann Agric Environ Med
2012; 19 (1):
ICID: 987307
Article type: Original article
Di-(2-ethylhexyl)phthalate (DEHP) is widely present in the human environment.
The study aimed at the investigation of potential genotoxic effects induced by subchronic exposure to DEHP in germ cells of male mice in the first period of puberty, and to check if the transmission of mutation to the next generation via the sperm is possible. 8-weeks exposure to 2,000 mg/kg and 8,000 mg/kg of DEHP diminished sperm count and quality, leading to a reduced percentage of pregnant females mated to exposed males. A slight increase in the frequency of prenatal deaths and dominant lethal mutations, as well as a significantly increased percentage of abnormal skeletons among the F1 offspring of males exposed to 8,000 mg/kg of DEHP, were observed. Exposure of the fathers did not cause a delay in the postnatal development of the offspring, except for fur development in the group of 8,000 mg/kg of DEHP. Gametes of male offspring of exposed fathers showed reduced motility. The results may suggest that diminished spermaozoa quality induced by DEHP may be coincidental with mutations leading to intrauterine deaths and skeletal abnormalities in the offspring.
PMID 22462442 - click here to show this article in PubMed

Recommend this article to:


Related articles in IndexCopernicus™
     DEHP [3 related records]
     Spermatozoa [315 related records]
     male-mediated effects [0 related records]
     progeny [5 related records]
     Mice [18176 related records]


Related articles

N  Relevy, A Harari,
Liarozole, an Inhibitor of Retinoic Acid Metabolis...
Liarozole is a Retinoic Acid Metabolism Blocking Agent (RAMBA). As retinoic acid (RA) and its precursor, beta-carotene (BC), have been shown to inhibit atherosclerosis development in mouse models, in the present study we investigated whether liarozol...
H Sameni , M Jadidi ,
بررسي اثرات عصاره هيدروالك...
سابقه و هدف: برخي از مطالعات نشان داده‌اند که عصاره هيدروالكلي دانه گياه عدس‌الملک داراي اثرات ضد صرعي، ضد ديابتي، کاهنده فشار خون بالا،...
A Showraki, M Emamghoreishi,
 Anticonvulsant Effect of the Aqueous Extract...
 Background: Carum carvi L. (caraway), known as black zeera in Iran, has been indicated for the treatment of epilepsy in Iranian folk medicine. This study evaluated whether the aqueous extract and essential oil of caraway seeds have anticonvulsa...