Valproic acid transfer across human placental cotyledon during dual perfusion in vitro.

Anna Semczuk-Sikora 1, Stanislaw Czuczwar 2, Andrzej Semczuk 2, Anna Kwasniewska 2, Marian Semczuk 2
1 - Department of Obstetrics, Medical University of Lublin, Lublin, Poland.
2 -
Ann Agric Environ Med
2010; 17 (1):
ICID: 982914
Valproic acid (VPA ) is a well-known antiepileptic drug with a significant teratogenic effect when administered during pregnancy. To investigate the transplacental transport of VPA, we used an in vitro experiment of dual perfusion of a human placental cotyledon. Eighteen normal placentas at term were investigated; ten were treated with a therapeutic dose of VPA (initial level at maternal circulation 75 microgram/ml), while the remaining eight were supplied with toxic VPA doses (initial level at maternal circulation 225 microgram/ml). VPA concentrations in fetal compartment were lower than those in the maternal compartment at all timepoints with both doses applied. The maternal and foetal VPA concentrations were stable at 60 min and 120 min for the therapeutic dose of VPA (transfer percentages from the maternal to the fetal circulation were 22.7 +- 9.1 percent and 22.7 +- 7.1 percent, respectively). Interestingly, a significant decrease of VPA level in the maternal perfusate was observed after 120 min due to the slightly higher transfer of the drug to the foetal compartment. In conclusion, our data confirmed an easy and rapid transfer of VPA accross the placental barrier. Since the incidence of congenital malformations in infants correlates positively with VPA concentrations in maternal serum, monitoring of VPA should be mandatory due to possible harmful effects on the foetus.
PMID 20684493 - click here to show this article in PubMed

Recommend this article to:


Related articles in IndexCopernicus™
     Valproic Acid [62 related records]


Related articles

E Bronisz, J Bembenek,
Molecular mechanisms of valproic acid action and i...
Valproic acid is a well-known drug long used in neurology as an antiepileptic drug and in psychiatry because of its mood-stabilising effect. Various mechanisms of valproic acid activity have been described (through gamma-aminobutyric acid system – ...
H Özcan, H Cenk,
Lamotrijin ve valproik asidin birlikte kullanımı...
Toksik epidermal nekroliz (TEN) nadir görülen, genellikle ilaç kullanımına bağlı gelişen, ani başlangıçlı, yaşamı tehdit eden, deri ve mukozaları etkileyen aşırı duyarlılık reaksiyonudur. Lamotrijin ve valproik asidin birlikte kul...
Effect of valproic acid on radiosensitivity to bre...
OBJECTIVE To study the effect of valproic acid (VPA) on radiosensitivity to MCF7 breast cancer cells. METHODS MCF7 cells were pretreated with VPA 0.5 and 1 mmol·L-1 for 0, 24, 48 and 72 h respectively, irradiated with 8 ...