Effect of lambda-cyhalothrin on memory and movement in mice after transient incomplete cerebral ischemia.

Barbara Nieradko-Iwanicka 1, Andrzej Borzecki 2
1 - Chair and Department of Hygiene, Medical University of Lublin, Radziwillowska 11, 20-080 Lublin, Poland. bnieradkoiwanicka@wp.pl.
2 -
Ann Agric Environ Med
2011; 18 (1):
ICID: 956867
 
 
Lambda-cyhalothrin (LCH) is a synthetic pyrethroid used as an insecticide. The aim of the study was to investigate the effect of LCH on memory, movement activity, and co-ordination in mice exposed to bilateral clamping of the carotid arteries (BCCA). On the first postsurgical day, the examined animals (BCCA/LCH) were injected with LCH i.p. and trained in the passive avoidance task 30 min. after the injection. Controls were: sham-operated animals (SHAM), with their carotids exposed but not occluded, animals subjected to BCCA (BCCA), and sham-operated mice injected with LCH (SHAM/ LCH). In the following experiments, memory retention, working spatial memory, movement activity, and co-ordination were examined. Neither memory nor movement co-ordination were impaired by BCCA or LCH. Exploratory locomotor activity was significantly reduced in the BCCA/LCH group (p < 0.01 vs SHAM). Spontaneous movement activity was significantly reduced in the BCCA/LCH group (p < 0.001 vs SHAM, p < 0.05 vs BCCA, p < 0.001 vs SHAM/LCH), as well as in the BCCA group (p < 0.01 vs SHAM). Exposure to LCH coexisting with BCCA decreased motor activity in the mice in 2 subsequent 30-min. periods of observation. BCCA itself decreased motor activity in the 31-60 min. of observation. These results show that BCCA combined with exposure to a subtoxic dose of LCH does not impair memory; however, they affect behaviour by reducing the horizontal movement activity in mice.
PMID 21736268 - click here to show this article in PubMed
  FULL TEXT STATS

Recommend this article to:

Name:
E-mail:
From:
Language:


Related articles in IndexCopernicus™
     lambda-cyhalothrin [2 related records]
     Memory [754 related records]
     Movement [632 related records]
     cerebral ischemia [49 related records]



 

Related articles

T Mojsik,
Arist. Rhet. 2.23.1398b and the cult of Pythagoras...
In the present article I would like to focus on three things: the usefulness of Alcidamas’s fragment (cited in Arist. Rhet. 2.23.1398b) for the procedure of establishing when the cult of poets/intellectuals began, the suitability of the terminology...
ABSTRACT
Z Ashrostaghi, F Ganji,
 Effect of metformin on the spatial memory in...
 Background: Aging process is often accompanied with some degree of decline in all the abilities, including learning and memory. One of the attracting research fields has been devoted to finding antiaging drugs. Metformin has shown some memory...
ABSTRACT
M Ashrafpour, S Parsaei,
 Quercetin improved spatial memory dysfunctio...
 Background: Alzheimer’s disease (AD) is one of the most common neurodegenerative syndromes characterized by a progressive decline in the spatial memory. There are convincing evidences on the neuroprotective effects of flavonoids against AD. ...
ABSTRACT