Effect of pesticides on kynurenic acid production in rat brain slices.

Elzbieta Zielińska 1, Tomasz Kocki 2, Tomasz Saran 2, Sandor Borbely 2, Damian Kuc 2, Ildiko Vilagi 2, Ewa M Urbańska 2, Waldemar A Turski 2
1 - Department of Toxicology, Institute of Agricultural Medicine, Lublin, Poland.
2 -
Ann Agric Environ Med
2005; 12 (2):
ICID: 848015
Article type: Original article
 
 
Kynurenic acid (KYNA) is a broad spectrum antagonist of ionotropic glutamate receptors, preferentially active at the strychnine-insensitive glycine allosteric site of the N-methyl-D-aspartate (NMDA) receptor, and a noncompetitive antagonist of alpha7 nicotinic receptor. Animal studies showed that it possesses anticonvulsant and neuroprotective properties. Its involvement in the pathophysiology of various brain disorders was suggested. In this study, the effect of pesticides on KYNA production in brain cortical slices was investigated. Pyrethroids, deltamethrin and fenpropathrin significantly lowered KYNA production. Methomyl, bensultap, fipronil, diquat and MCPA were ineffective in this regard. In view of this data, the inhibition of KYNA synthesis appear to merit further investigation as a potential factor contributing to the toxicology of pyrethroids.
PMID 16457470 - click here to show this article in PubMed
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