Neurotoxic effect of dermally applied chlorpyrifos and cypermethrin. Reversibilityof changes.

Daniela Przebirowska 1, Malgorzata Tokarska-Rodak 1, Grzegorz Raszewski 1, Sabina Luty 1, Jadwiga Latuszynska 2
1 -
2 - Department of Pathomorphology, Institute of Agricultural Medicine, 20-950 Lublin,Poland.
Ann Agric Environ Med
2003; 10 (2):
ICID: 142710
Nurelle D 550 EC preparation (Dow Elanco, USA) was applied in the study.The contents of biologically active substances in 1l of the preparation was: 500 g chlorpyrifos and 50g of cypermethrin. The experimental studies were conducted on 4 groups of rats (2 control - 10 animalsin each group, and 2 experimental - 40 animals in each group). The experimental groups were dermallyadministered a mixture of 27.8 mg/cm(2) of chlorpyrifos and 2.7 mg/cm(2) of cypermethrin for a periodof 1 week and 4 weeks (4 h daily). The control groups did not participate in the experiment. Blood wastaken from the heart after 1 day, 1 week, 2 and 3 weeks after the administration of the preparation inorder to determine cholinesterase activity in serum, and the brain was taken to evaluate brain cholinesteraseactivity. The brain for histologic studies was taken from rats 3 weeks after the experiment. The cholinesteraselevels in the serum and brain initially decrease and then return to normal at 2 and 3 weeks post-exposure,respectively. Slight histopathological changes in various areas of the brain as well as increased densityof the cytoplasm in neurocytes in both experimental groups were observed 3 weeks post-exposure.
PMID 14677911 - click here to show this article in PubMed

Recommend this article to:


Related articles in IndexCopernicus™
     Pyrethrins - toxicity [47 related records]
     Pyrethrins - administration & dosage [24 related records]
     Chlorpyrifos - toxicity [19 related records]
     Chlorpyrifos - administration & dosage [5 related records]


Related articles

G Raszewski, R Chwedorowicz,
Homocysteine, antioxidant vitamins and lipids as ...
Introduction and objective. Evidence for the benefit of antioxidants’ based therapeutic intervention in dementia are inconsistent. Parallel studies in disease forms of dementia different than Alzheimer’s are even less conclusive. In this s...
W Luty,
I Bojar, J Owoc,
Cognitive functions, lipid profile, and Apolipopro...
The objective of the study was investigation of the relationship between cognitive functions and lipid profile, BMI and change of body weight in postmenopausal women carriers of Apolipoprotein E gene polymorphisms (APOE). A group of 170 women was rec...