Correlation between the single, high dose of ingested baclofen and clinical symptoms

Jacek Sein Anand 1, Maciej Zając 1, Wojciech Waldman 1, Andrzej Wojtyła 2, Przemysław Biliński 2, Barbara Jaworska-Łuczak 3
1 - Department of Clinical Toxicology, Medical University of Gdansk, Poland; Pomeranian Center of Toxicology, Poland
2 - Department of Medicine, Higher Vocational State School in Kalisz, Poland
3 - Office for Registration of Medicinal Products, Medical Devices and Biocidal Products, Warsaw, Poland
Ann Agric Environ Med

ICID: 1230735
Article type: Original article
 
 
Introduction and Objectives. Baclofen is a drug used mainly to treat muscle spasticity. Its overdose can lead to life-threatening clinical symptoms, including acute respiratory failure requiring mechanical ventilation. The aim of this study was to assess the prevalence of selected clinical symptoms associated with baclofen poisoning comparing to an ingested dose.
Materials and method. 60 cases of oral baclofen poisoning were analyzed. Gender, age distribution, and correlation between the dose of ingested baclofen were studied, as well as and following clinical parameters: degree of altered consciousness, heart rate, blood pressure, presence of acute respiratory failure, duration of mechanical ventilation, and presence of psychotic symptoms.
Results. The study found statistically significant correlations between dosage of ingested baclofen and presence of acute respiratory failure, as well as duration of mechanical ventilation. No statistically significant correlations were found between the dose of ingested baclofen and presence of hypertension, bradycardia, acute psychotic symptoms, or level of consciousness disturbance. However, it was found that patients who suffered from hypertension, bradycardia, and altered mental status ingested a larger dose of baclofen.
Conclusions. There is a statistically significant correlation between the dose of ingested baclofen and the presence of acute respiratory failure, and duration of mechanical ventilation. Patients who have taken a single dose of baclofen of 200 mg, or higher, should be managed in centres able to provide continuous monitoring of life functions. Those with a higher level of a single dose of baclofen ingestion (>500 mg), should be hospitalized in a Toxicology Unit or Intensive Care Unit able to provide airway support and mechanical ventilation

DOI: 10.5604/12321966.1230735
  FULL TEXT STATS

Recommend this article to:

Name:
E-mail:
From:
Language:


Related articles in IndexCopernicus™
     acute poisoning, [2 related records]
     acute respiratory failure [7 related records]
     baclofen [27 related records]
     mechanical ventilation [56 related records]



 

Related articles

, ,
Application of synchronization with two ventilator...
Background and Objective: Some of multiple trauma patients admitted in ICU (Intensive Care Unit) are intubated and ventilated by mechanical ventilation. These patients are prone to many complications such as lung disease. Reasons for this complicatio...
ABSTRACT
A PRASSAS, A ATHANASIOU,
Intrathecal baclofen administration for the treatm...
NO abstract available...
ABSTRACT
N P. C, S K. S,
 OUTCOME OF VENTILATION IN HYALINE MEMBRANE D...
 OBJECTIVE To study the short-term outcome of both preterm and term babies requiring assisted ventilation for hyaline membrane disease and report the complications contributing to morbidity and mortality of these patients from a regional medi...
ABSTRACT