Sublingual immunotherapy (SLIT) – indications, mechanism, and efficacy
Position paper prepared by the Section of Immunotherapy, Polish Society of Allergy

Marek Jutel 1, Małgorzata Bartkowiak-Emeryk 2, Anna Bręborowicz 3, Ewa Cichocka-Jarosz 4, Andrzej Emeryk 5, Radosław Gawlik 6, Paweł Gonerko 7, Barbara Rogala 8, Anna Nowak-Węgrzyn 9, Bolesław Samoliński 10, and other members of IT Section PTA 11
1 - Wroclaw Medical University, Wrocław, Poland
2 - Chair of Clinical Immunology, Department of Clinical Immunology, University of Medicine, Lublin, Poland
3 - Department of Pneumonology, Allergology and Clinical Immunology, Poznan University of Medical Sciences, Poland
4 - Chair of Pediatrics, Department of Pediatrics, Jagiellonian University Medical College, Krakow, Poland
5 - Department of Lung Diseases and Rheumatology, University of Medicine, Lublin, Poland
6 - Chair and Department of Internal Medicine, Allergy, Clinical Immunology, Medical University of Silesia, Katowice, Poland
7 - I Department of Pediatrics, Allergy and Pulmonology, Szczecin, Poland
8 - Chair and Department of Internal Medicine, Allergy, Clinical Immunology, Medical University of Silesia, Katowice, Poland
9 - Icahn School of Medicine at Mount Sinai Hospital, New York, US
10 - Department of Prevention of Envinronmental Hazards and Allergology, Medical University, Warszawa, Poland
11 - PTA
Ann Agric Environ Med
2016; 23 (1):
ICID: 1196851
Article type: Review article
 
 
SLIT (sublingual immunotherapy,) induces allergen-specific immune tolerance by sublingual administration of a gradually increasing dose of an allergen. The mechanism of SLIT is comparable to those during SCIT (subcutaneous immunotherapy), with the exception of local oral dendritic cells, pre-programmed to elicit tolerance. In the SLIT dose, to achieve the same efficacy as in SCIT, it should be 50–100 times higher with better safety profile. The highest quality evidence supporting the efficacy of SLIT lasting 1 – 3 years has been provided by the large scale double-blind, placebo-controlled (DBPC) trials for grass pollen extracts, both in children and adults with allergic rhinitis. Current indications for SLIT are allergic rhinitis (and conjunctivitis) in both children and adults sensitized to pollen allergens (trees, grass, Parietaria), house dust mites (Dermatophagoides pteronyssinus, Dermatophagoides farinae), cat fur, as well as mild to moderate controlled atopic asthma in children sensitized to house dust mites. There are positive findings for both asthma and new sensitization prevention. Severe adverse events, including anaphylaxis, are very rare, and no fatalities have been reported. Local adverse reactions develop in up to 70 – 80% of patients. Risk factors for SLIT adverse events have not been clearly identified. Risk factors of non-adherence to treatment might be dependent on the patient, disease treatment, physician-patient relationship, and variables in the health care system organization.
DOI: 10.5604/12321966.1196851
PMID 27012173 - click here to show this article in PubMed
  FULL TEXT STATS

Recommend this article to:

Name:
E-mail:
From:
Language:


Related articles in IndexCopernicus™
     allergen/therapeutic use [0 related records]
     immunologic/methods [1 related records]
     desensitization [9 related records]
     Adult [91069 related records]
     Child [31045 related records]



 

Related articles

E Sarı, E Ataş,
Inflammatory Myofibroblastic Tumor Presenting with...
Inflammatory myofibroblastic tumors (IMT) develop as a non-neoplastic proliferation of myofibroblasts in a myxoid to collagenous stroma admixed with inflammatory cells. The symptoms depend on the specific location of the tumor, which can be anywhere...
ABSTRACT
F Aktar, A Güneş,
İnfluenza virüsü (H1N1)’ne sekonder gelişen ...
İnfluenza, sağlıklı çocuklarda genellikle kendi kendini sınırlayan, akut ve komplikasyonsuz bir hastalık olsa da nadiren ciddi hastalık tablosu oluşturup ölüme neden olabilir. Enfeksiyonun en sık komplikasyonu pnömoni olup, miyokardit i...
ABSTRACT
D Queiroz, M Amorim,
Quality of life of children and adolescents with c...
Objective. To assess the quality of life of children and adolescents with cancer of studies that applied the Pediatric Quality of Life Inventory 3.0 Cancer Module. Methodology. The study was carried out on the basis of data Scopus Web of Science, BIR...
ABSTRACT