Evaluation of CD40 and CD80 receptors in the colonic mucosal membrane of children with inflammatory bowel disease

Barbara Kamińska 1, Izabela Roszko-Kirpsza 2, Piotr Landowski 2, Agnieszka Szlagatys- Sidorkiewicz 1, Katarzyna Guzińska-Ustymowicz 3, Elżbieta Maciorkowska 2
1 - Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, Poland
2 - Department of Developmental Age Medicine and Paediatric Nursing, Medical University of Bialystok, Poland
3 - Department of Pathomorphology, Medical University of Bialystok, Poland
Ann Agric Environ Med
2015; 22 (4):
ICID: 1185778
Article type: Original article
Introduction. The most prevalent inflammatory bowel diseases (IBD) include ulcerative colitis (UC) and Crohn’s disease (CD). Immune processes play a vital role in the etiopathogenesis of these conditions, involving both cellular and humoral response mechanisms. The aim of this study was to quantify CD40- and CD80-positive cells in the biopsy specimens of large intestinal mucosa from children with IBD.
Materials and method. The study comprised 38 children aged between 3–17 years (mean 11.5±3.7 years) – 20 boys (52.6 %) and 18 girls (47.4%). Eighteen patients were diagnosed with UC on the basis of clinical manifestation, endoscopic and histopathological findings. Mean age of this subgroup was 11.55±4.07 years. A group of 10 children (mean age 12.30±2.83) diagnosed with CD was also included. The control group comprised 10 IBD-free children (mean age 10.28±4.07 years). The surface expressions of CD40 and CD80 were analyzed in large intestine mucosa biopsy specimens, fixed in formaldehyde, embedded in paraffin, and cut with a microtome into 4 µm slices.
Results. The number of CD40- and CD80-positive cells in the large intestinal mucosa of children with Crohn’s disease and ulcerative colitis was significantly higher than in the controls. The highest number of CD40+ and CD80+ cells was observed in the caecal mucosal membrane of Crohn’s disease patients and in the rectal mucosa of individuals with ulcerative colitis.
Conclusion. IBD is characterized by elevated, segment-specific, expression of CD40 and CD80.
DOI: 10.5604/12321966.1185778
PMID 26706980 - click here to show this article in PubMed

Recommend this article to:


Related articles in IndexCopernicus™
     CD40, CD 80 receptors [0 related records]
     children [3227 related records]
     inflammatory bowel disease [149 related records]


Related articles

P Gupta, M Mittal,
 A hospital based retrospective study on hepa...
 Introduction: Acute viral hepatitis in children is a serious health problem throughout the world. Aims and Objective: To determine the profile of Hepatitis A, B, C and E as a cause of acute viral hepatitis in children in a tertiary care hospita...
M Trivedi, H Patil,
OBJECTIVES: This study was conducted to know the distribution of intestinal tuberculosis in various age groups and sex, and to study common presenting symptoms and frequency of involvement of different sites in intestinal tuberculosis. M...
O Evliyaoğlu, M Acar,
Vitamin D Deficiency and Hashimoto’s Thyroiditis...
Objective: Vitamin D has been suggested to be active as an immunomodulator in autoimmune diseases such as Hashimoto’s thyroiditis (HT). The goal of the present study was to investigate the vitamin D status in HT patients. Methods: This prevalence ...