Evaluation of CD40 and CD80 receptors in the colonic mucosal membrane of children with inflammatory bowel disease

Barbara Kamińska 1, Izabela Roszko-Kirpsza 2, Piotr Landowski 2, Agnieszka Szlagatys- Sidorkiewicz 1, Katarzyna Guzińska-Ustymowicz 3, Elżbieta Maciorkowska 2
1 - Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, Poland
2 - Department of Developmental Age Medicine and Paediatric Nursing, Medical University of Bialystok, Poland
3 - Department of Pathomorphology, Medical University of Bialystok, Poland
Ann Agric Environ Med
2015; 22 (4):
ICID: 1185778
Article type: Original article
 
 
Introduction. The most prevalent inflammatory bowel diseases (IBD) include ulcerative colitis (UC) and Crohn’s disease (CD). Immune processes play a vital role in the etiopathogenesis of these conditions, involving both cellular and humoral response mechanisms. The aim of this study was to quantify CD40- and CD80-positive cells in the biopsy specimens of large intestinal mucosa from children with IBD.
Materials and method. The study comprised 38 children aged between 3–17 years (mean 11.5±3.7 years) – 20 boys (52.6 %) and 18 girls (47.4%). Eighteen patients were diagnosed with UC on the basis of clinical manifestation, endoscopic and histopathological findings. Mean age of this subgroup was 11.55±4.07 years. A group of 10 children (mean age 12.30±2.83) diagnosed with CD was also included. The control group comprised 10 IBD-free children (mean age 10.28±4.07 years). The surface expressions of CD40 and CD80 were analyzed in large intestine mucosa biopsy specimens, fixed in formaldehyde, embedded in paraffin, and cut with a microtome into 4 µm slices.
Results. The number of CD40- and CD80-positive cells in the large intestinal mucosa of children with Crohn’s disease and ulcerative colitis was significantly higher than in the controls. The highest number of CD40+ and CD80+ cells was observed in the caecal mucosal membrane of Crohn’s disease patients and in the rectal mucosa of individuals with ulcerative colitis.
Conclusion. IBD is characterized by elevated, segment-specific, expression of CD40 and CD80.
DOI: 10.5604/12321966.1185778
PMID 26706980 - click here to show this article in PubMed
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