Superoxide dismutase and glutathione peroxidase activity in pregnancy complicated by diabetes

Artur Wdowiak 1, Ireneusz Brzozowski 2, Iwona Bojar 3
1 - Diagnostic Techniques Unit, Faculty of Health Sciences, Medical University in Lublin, Poland
2 - Luxmed Medical Center, Lublin, Poland
3 - Department for Health Problems of Ageing, Institute of Rural Health, Lublin, Poland
Ann Agric Environ Med
2015; 22 (2):
ICID: 1152083
Article type: Original article
The objective of the study was determination of the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in blood and placental tissues of pregnant women with pregnancy complicated by diabetes, pregnant women with physiological pregnancy, and non-pregnant women, as well as a comparative analysis of blood and placental tissue parameters in the groups of women examined. The material for the study was blood and placental tissue from 50 pregnant women who received treatment due to insulin-dependent diabetes (PD). For the control group, 50 pregnant women without diabetes (HP), and 30 non-pregnant women (NP) were selected. SOD activity in erythrocytes was evaluated by the method of spectrophotometry with the use of RANSOD kit (RANDOX Laboratories Ltd., UK). The activity of GPx activity in erythrocytes was determined according to the method by Paglia and Valentine using RANSEL kit (RANDOX Laboratories Ltd). The results were subject to statistical analysis. Insulin-dependent diabetes in pregnancy affects the activity of anti-oxidative enzymes. In the blood of women with pregnancy complicated by diabetes, the activity of anti-oxidative enzymes – SOD and GPx is higher than in the blood of women with physiological pregnancy and the control group. In the placental tissue from pregnancy complicated by diabetes, the activity of SOD significantly decreases, while the activity of GPx increases, compared to women in physiological pregnancy.
DOI: 10.5604/12321966.1152083
PMID 26094527 - click here to show this article in PubMed

Recommend this article to:


Related articles in IndexCopernicus™
     diabetes [969 related records]
     Pregnant Women [157 related records]
     Glutathione Peroxidase [65 related records]
     Superoxide Dismutase [192 related records]


Related articles

K Walkiewicz, A Nasiek-Palka,
Znaczenie substancji aktywnych pochodzenia roślin...
V Nagar,  Gour,
A study to assess the blood glucose level among di...
Background: The incidence of diabetes mellitus (DM) is increasing worldwide, especially in developing countries where tuberculosis (TB) is most prevalent. Nearly one-third of world ’ s population is infected with Mycobacterium tuberculosis . ...
,  Singh,
Effect of Eclipta Alba against blood glucose level...
In this modern age, people are moving towards nature to treat the diseases to avoid the side effects of the allopathic drugs. Diabetes Mellitus is one such important disease, constituently increasing prevalence globally and is one of the most challen...