Postpartum adiponectin changes in women with gestational diabetes

Beata Matyjaszek-Matuszek 1, Monika Lenart- Lipińska 2, Jolanta Kowalczyk-Bołtuć 3, Sławomir Wożniak 4, Tomasz Paszkowski 4
1 - Chair and Department of Endocrinology, Medical University of Lublin
2 - Department of Laboratory Diagnostics, Medical University of Lublin
3 - Institute of Rural Health in Lublin
4 - 3rd Chair and Department of Gynecology, Medical University of Lublin
Ann Agric Environ Med
2014; 21 (4):
ICID: 1129945
Article type: Original article
introduction and objective. Current literature provides contradictory information on the role of adiponectin (AdipoQ) in the course of gestational diabetes mellitus (GDM) and the changes after delivery. The aim of the study was to measure AdipoQ concentration in blood of women with GDM, and to conduct a comparative analysis of AdipoQ concentrations in gestation at 3 and 12 months after delivery.
material and methods. The study group consisted of 50 women diagnosed with GDM between 24 and 28 weeks of gestation. Three months after delivery, 41 women underwent further tests, while 12 months after delivery 30 patients. All patients underwent clinical and laboratory evaluation at GDM diagnosis at 3 and 12 months after delivery. Laboratory evaluation included fasting glucose, fasting insulin, OGTT and lipid parameters in serum. Serum AdipoQ concentration was measured at GDM diagnosis as well as at 3 and 12 months after delivery.
results. AdipoQ concentrations did not differ significantly between the groups during gestation (p=0.7054) and 3 months after delivery (p=0.9732), while a significant rise was observed 12 months after delivery, compared to the values during pregnancy (p=0.0006). AdipoQ in the GDM group 12 months after delivery inversely correlated with fasting glucose and 2-hour post-load plasma glucose after a 75-g oral glucose tolerance test (r=-0.37 * ; p<0.05 and r=-0.42, p<0.05, respectively).
conclusions. An increased level of AdipoQ after delivery in the comparison to women with GDM may be a marker for reversibility of carbohydrate metabolism disorders, while a negative correlation between AdipoQ and glucose levels suggests that this parameter may be a predictor In the future of disturbances in glucose tolerance in women with GDM.

DOI: 10.5604/12321966.1129945
PMID 25528933 - click here to show this article in PubMed

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