Disturbance of posture in children with very low lead exposure, and modification by VDR FokI genotype
Natalia Pawlas 1, Karin Broberg 2, Staffan Skerfving 2, Krystyna Pawlas 3 1 - Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland 2 - Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund, Sweden 3 - Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland; Department of Hygiene, Wroclaw Medical University, Wroclaw, Poland Ann Agric Environ Med 2014; 21 (4): ICID: 1129926 Article type: Original article
Introduction and objective. Lead has a negative effect on the central nervous system (CNS), inter alia indicated by disturbance of posture. However, knowledge of the CNS effects at low exposure is insufficient. Individuals differ in vulnerability, possibly because of genetic predisposition. Polymorphisms in the δ-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genes may modify lead metabolism and neurotoxicity.
The objective of the study was to determine whether very low lead exposure affects posture in children, and whether ALAD and VDR genotypes modify the effect.
Materials and methods. In 1996–2001, 108 (age 5–13, mean 6.9), and in 2008–2010 231 (age 5–11, mean 7.9) children from Poland were tested by posturography and blood-lead concentration (B-Pb; medians 50 and 36 µg/L, respectively). The children were genotyped for ALAD (RsaI, MspI) and VDR (FokI, BsmI, TaqI). Results. There were correlations between posture and B-Pb (sway area with closed eyes: rS=0.24, P<0.001; velocity: rS=0.21, P<0.001). Significant effects (adjusted for the potential confounders height and mother´s education) were present already at (ln-transformed) B-Pb <50 µg/L [β (regression coefficient) for sway area 0.025, p=0.001), and even stronger than at higher levels (β=0.006, p=0.06, respectively)]. The ff carriers in VDR FokI polymorphism were more susceptible to the effect of lead on the balance system, while other VDR or ALAD genotypes did not significantly modify the effect. Conclusions. Effects on CNS, as reflected by disturbances of posture, were present at very low lead exposure (B-Pb <50 µg/L), and the effect was significantly greater at such low B-Pbs than at higher. VDR FokI significantly modified the effect.
DOI: 10.5604/12321966.1129926 PMID 25528913 - click here to show this article in PubMed