Raised concentrations of lipid peroxidation products (LPO) in pregnant women with impaired glucose tolerance

Krzysztof C. Lewandowski 1, Nemanja Stojanovic 2, Martin Press 3, Susan Tuck 4, Andrzej Lewiński 5, Małgorzata Karbownik-Lewińska 6
1 - Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland, Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital – Research Institute, Lodz, Poland
2 - Department of Diabetes and Endocrinology, Royal Free Hospital, Hampstead, London, UK
3 - Department of Diabetes and Endocrinology, Royal Free Hospital, Hampstead, London, UK
4 - Department of Obstetrics and Gynaecology, Royal Free Hospital, Hampstead, London, UK
5 - Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland, Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital – Research Institute, Lodz, Poland
6 - Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital – Research Institute, Lodz, Poland, Department of Oncological Endocrinology, Medical University of Lodz, Lodz, Poland
Ann Agric Environ Med
2014; 21 (2):
ICID: 1108619
Article type: Original article
 
 
introduction. Lipid peroxidation (LPO) results from oxidative damage to membrane lipids. Whereas LPO rises in normal pregnancy, the effect of gestational diabetes mellitus (GDM) on this process has not been clearly defined.
materials and method. Fasting blood concentrations of malondialdehyde+4-hydroxyalkenals (MDA+4-HDA), as LPO index, TNFa soluble receptors (sTNF-R1 and sTNF-R2), and soluble adhesion molecules (sICAM-1, sVCAM-1), were measured in 51 women at 28 weeks of gestation. The women were divided according to the results of 50.0 g glucose challenge test (GCT) and 75.0 g oral glucose tolerance test (OGTT): Controls (n=20), normal responses to both GCT and OGTT; Intermediate Group
(IG) (n=15), abnormal GCT but normal OGTT; GDM group (n=16), abnormal both GCT and OGTT.
results. Glucose concentrations in women diagnosed with GDM were within the range of impaired glucose tolerance. There were no significant differences in concentrations of either TNF a soluble receptors R1 and R2, or sICAM-1 or sVCAM-1. LPO concentrations [MDA+4-HDA (nmol/mg protein)] were significantly higher in women with GDM than in the other two groups [64.1±24.3 (mean±SD), 39.3±23.1, 47.0±18.1, for GDM, IG and Controls, respectively; p<0.05]. In multivariate analysis, the only significant independent correlation was between LPO level and glucose at 120 minutes of OGTT (rs=0.42; p=0.009).
conclusions. Oxidative damage to membrane lipids is increased in GDM and might result directly from hyperglycaemia. Physiological significance of this phenomenon remains to be elucidated.
DOI: 10.5604/1232-1966.1108619
PMID 24959804 - click here to show this article in PubMed
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