The role of hepcidin and haemojuvelin in the pathogenesis of iron disorders in patients with severe malnutrition

Justyna Przybyszewska 1, Ewa Żekanowska 2
1 - Department of Nutrition and Dietetics, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Poland
2 - Department of Pathophysiology, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Poland
Ann Agric Environ Med
2014; 21 (2):
ICID: 1108600
Article type: Review article
 
 
introduction and objective. The clinical consequences of malnutrition are multi-directional and result in dysfunctions of the majority of internal organs and systems. The results of recent studies suggest that a significant role is played by malnutrition in pathophysiology of iron homeostasis disorders, but the underlying mechanism is unclear. The study describes the potential role of hepcidin and hemojuvelin in the pathogenesis of disorders of iron metabolism during malnutrition.
state of knowledge. The participation of hepcidin in regulating iron homeostasis encompasses inhibiting the absorption of food iron from enterocytes and inhibiting the release of stored iron from the reticuloendothelial system cells. One of the factors that increases the post-translational level is the expression of hepcidin is IL-6. In studies focused on malnutrition it was observed that in persons with protein and energy deficits the level of proinflammatory cytokine, i.e. interleukin-6, in the serum, increased. The involvement of haemojuvelin in the overall iron homeostasis is related with the regulation of expression of the hepcidin coding gene on the transcription level. The highest haemojuvelin expression was observed in humans in skeletal muscles. Observations and analyses conducted in vivo allowed the conclusion that soluble HJV and cell-related haemojuvelin regulate hepcidin expression in response to changes in iron concentration. The research also demonstrated that soluble HJV neutralizes the inductive effect of IL-6 action on hepcidin expression.
summary. It can be claimed that in persons with protein and/or protein-energetic malnutrition the muscle mass deficit may lead to insufficient production of haemojuvelin and sideropenia.
DOI: 10.5604/1232-1966.1108600
PMID 24959785 - click here to show this article in PubMed
  FULL TEXT STATS

Recommend this article to:

Name:
E-mail:
From:
Language:


Related articles in IndexCopernicus™
     malnutrition [150 related records]
     iron disorders [0 related records]
     haemojuvelin [0 related records]
     hepcidin [21 related records]



 

Related articles

P Singh, B Mukherjee,
  ASSESSMENT OF NUTRITIONAL STATUS BY MID UP...
  An observational study of 500 children (267 boys and 233 girls) was undertaken during 2008-2010 at primary health centres under the aegis of Katihar Medical College in Kosi region of Bihar to assess their nutritional status using mid upper...
ABSTRACT
N Hejazi, Z Mazloom,
 Nutritional Assessment in Critically Ill P...
 Background: Malnutrition is an important factor in the survival of critically ill patients. The purpose of the present study was to assess the nutritional status of patients in the intensive care unit (ICU) on the days of admission and discharg...
ABSTRACT
S Lahiri, A Biswas,
Assessment of nutritional status among elderly pop...
Background: Geriatric population is a potentially vulnerable group for malnutrition as per 2002 census of the World Health Organization. Objectives: To estimate the prevalence of malnutrition and risk of malnutrition among elderly population i...
ABSTRACT