Diagnostic methods of TSH in thyroid screening tests                       

Beata Matyjaszek-Matuszek 1, Aleksandra Pyzik 1, Andrzej Nowakowski 1, Mirosław J Jarosz 2
1 - Department of Endocrinology, Medical University, Lublin, Poland
2 - Department of Health Informatics and Statistics, Institute of Rural Health, Lublin, Poland; Faculty of Pedagogy and Psychology, University of Economics and Innovation, Lublin, Poland
Ann Agric Environ Med
2013; 20 (4):
ICID: 1081381
Article type: Review article
 
 
Introduction: Reliable and quick thyreologic diagnostics, as well as verification of the effectiveness of the therapy undertaken, is of great importance for the state of health of society. The measurement of plasma TSH is the commonly accepted and most sensitive screening test for primary thyroid disorders, which are the most frequent diseases related to the endocrine glands. At present, the available methods for the determination of TSH are characterized by high sensitivity ≤0.01 µIU/ml and lack of cross-reactivity. However, many drugs and substances, as well as pathological conditions, may affect the TSH level.
Objective: evaluation of contemporary laboratory methods for the determination of TSH and the principles of interpretation of screening tests.
State of knowledge: In many countries, the TSH test is the only test performed in the diagnostics of thyroid function; nevertheless, it seems that for genuine and objective assessment of thyroid status the TSH level, together with FT4 level, should be absolutely determined, which allows the differentiation and assessment of the intensity of thyroid function disorders and foresee its consequences. The interpretation of TSH results in screening tests is different in such population groups as: children aged under 14, pregnant women, the elderly, and patients with non-thyroidal illnesses.
Conclusions: From among currently used laboratory methods for determination of TSH levels, third generation non-isotopic methods are most frequently recommended, especially the method of immunochemiluminescence.
PMID 24364444 - click here to show this article in PubMed
  FULL TEXT STATS

Recommend this article to:

Name:
E-mail:
From:
Language:


Related articles in IndexCopernicus™
     TSH [7 related records]
     screening laboratory tests [0 related records]
     thyroid disorders [7 related records]



 

Related articles

P Skonieczek, M Nowakowski,
Influence of selected Rhizoctonia solani isolates ...
From 2008 to 2010 the levels of sugar beet seedlings infection caused by Rhizoctonia solani were compared in laboratory tests. Seven sugar beet lines were tested: H56, H66, S2, S3, S4, S5 and S6 as well as three control cultivars: Carlos, Esperanza a...
ABSTRACT
M Chodnicki, P Kordowski,
ALGORITHMS FOR DETECTING DISORDERS OF THE BLDC MO...
Unmanned aerial vehicles are used to observe objects from the air in both kind of users – military and civilian. During the flight, UAV constantly is changing its orientation. This is due to weather conditions and commands coming from the ground co...
ABSTRACT
A Nowakowski,
Bibliografia Tatr i Podhala Zofii i Witolda Parysk...
Region Tatr i Podhala – z uwagi na miejsce, jakie zajmuje w świadomości społecznej, ale również i w literaturze – od zawsze wymagał opracowania zestawiającego dorobek piśmienniczy związany z kulturą, geografią, etnografią i wieloma ...
ABSTRACT