The efficacy of cognitive rehabilitation with RehaCom programme in schizophrenia patients. The role of selected genetic polymorphisms in successful cognitive rehabilitation

Monika Mak 1, Jerzy Samochowiec 1, Piotr Tybura 1, Przemyslaw Bieńkowski 2, Beata Karakiewicz 3, Liliana Zaremba Pechmann 3, Bożena Mroczek 3
1 - Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland
2 - Department of Pharmacology, Institute of Psychiatry and Neurology, Warsaw, Poland
3 - Public Health Department, Pomeranian Medical University, Szczecin, Poland
Ann Agric Environ Med
2013; 20 (1):
ICID: 1041677
Article type: Original article
 
 
Introduction. Schizophrenic patients present cognitive dysfunctions which are regarded to be one of endophenotypical markers predisposing to schizophrenia. Currently, schizophrenia can be treated as a neurodegenerative and neurodeveloping disease with genetic background.
Objective. Assessment of the possible positive effect of neuropsychological rehabilitation in schizophrenia, in patients presenting cognitive dysfunctions. An additional aim was to verify the hypothesis that some genetic polymorphisms can be a prognostic factor for success in neuropsychological rehabilitation.
Material and methods. 41 participants and 40 control subjects were randomly selected. Both groups had the diagnosis of paranoid schizophrenia. Cognitive functions were checked with the Wisconsin Card Sorting Test, Trail Making Test, and Stroop Test at the beginning and end of the experiment. In the research group, each patient trained with the rehabilitation programme RehaCom, whereas the control group did not receive such training. Genes COMT rs4680 and BDNF rs6265 were analysed in the genetic part of study.
Results. RehaCom procedures appear to be useful in the neuropsychological rehabilitation of cognitive dysfunctions in patients diagnosed with schizophrenia. The research group showed a moderate improvement in the training programmes.
Analysis of parameters obtained in the neuropsychological tests showed a slight improvement in both groups. At the present time, analysis of the polymorphisms of genes cannot be treated as a prognostic factor for the success of neuropsychological rehabilitation because statistical analyses showed few dependences with little statistical significance.
Conclusions. Cognitive rehabilitation produces moderate improvement in cognitive functioning.
PMID 23540216 - click here to show this article in PubMed
  FULL TEXT STATS

Recommend this article to:

Name:
E-mail:
From:
Language:


Related articles in IndexCopernicus™
     genes’ polymorphisms [0 related records]
     COMT [9 related records]
     BDNF [30 related records]
     Wisconsin Card Sorting Test [2 related records]
     RehaCom [3 related records]
     Schizophrenia [716 related records]
     neurorehabilitation [23 related records]
     cognitive functions [99 related records]



 

Related articles

D Kordi-Tamandani , A Bahrami,
Analysis of IL-33 gene polymorphism (rs11792633 C/...
Recently, inflammation has been found to be a significant factor in the development of Schizophrenia (SCZ). The aim of the present research was to investigate whether interleukin-33 (IL-33, OMIM: 608678) gene polymorphism (rs11792633, C/T) is associa...
ABSTRACT
W Kordas, K Kokodyńska,
Family and schizophrenia - psychoeducational group...
ObjectivesThe paper aims to present the programme, the outcomes and the conclusions of a psychoeducational training series for families with schizophrenia carried out by the Babiński Specialist Hospital in Kraków, Poland. The paper sets out to desc...
ABSTRACT
P de Moura, F Couto,
The Mesolimbic Dopaminergic Dysfunction in Psychos...
Background: For several decades now it is thought that dopamine hyperactivity on the mesolimbic pathway is implied on the genesis of schizophrenic psychotic symptoms. Aims: In this review we sought to interconnect the various areas of ...
ABSTRACT