Silver nanoparticles – allies or adversaries?

Teresa Bartlomiejczyk 1, Anna Lankoff 2, Marcin Kruszewski 3, Irena Szumiel 4
1 - Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warsaw, Poland
2 - Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warsaw, Poland,Jan Kochanowski University, Kielce, Poland
3 - Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warsaw, Poland, Independent Laboratory of Molecular Biology, Institute of Rural Health, Lublin, Poland
4 - Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warsaw, Poland
Ann Agric Environ Med
2013; 20 (1):
ICID: 1041674
Article type: Review article
 
 
Nanoparticles (NP) are structures with at least one dimension of less than 100 nanometers (nm) and unique properties. Silver nanoparticles (AgNP), due to their bactericidal action, have found practical applications in medicine, cosmetics, textiles, electronics, and other fields. Nevertheless, their less advantageous properties which make AgNP potentially harmful to public health or the environment should also be taken into consideration. These nanoparticles are cyto- and genotoxic and accumulate in the environment, where their antibacterial properties may be disadvantageous for agriculture and waste management. The presented study reviews data concerning the biological effects of AgNP in mammalian cells in vitro: cellular uptake and excretion, localization in cellular compartments, cytotoxicity and genotoxicity. The mechanism of nanoparticle action consists on induction of the oxidative stress resulting in a further ROS generation, DNA damage and activation of signaling leading to various, cell type-specific pathways to inflammation, apoptotic or necrotic death. In order to assure a safe application of AgNP, further detailed studies are needed on the mechanisms of the action of AgNP on mammalian cells at the molecular level.
PMID 23540211 - click here to show this article in PubMed
  FULL TEXT STATS

Recommend this article to:

Name:
E-mail:
From:
Language:


Related articles in IndexCopernicus™
     in vitro toxicity testing [0 related records]
     genotoxicity [37 related records]
     cytotoxicity [195 related records]
     Silver [75 related records]
     Nanoparticles [196 related records]



 

Related articles

S Ayatollahi Mousavi, S Pourtalebi,
Inhibitory Effects of Silver Nanoparticles on Grow...
Background: Aflatoxins (AFs) are secondary hazardous fungal metabolites that are produced by strains of some Aspergillus species on food and feedstuffs. Aflatoxin B1 (AFB1) is one of the most important AF with high toxicity. Prevention of AF producti...
ABSTRACT
M Kacprzak, J Bień,
Application of sludge and environmental safety&nbs...
In view of the upcoming ban on sending sludge to landfills, the question of its environmentally safe application become more im- portnant. Until recently, it was believed that the biggest problem of chemical contaminants present in the sludge is p...
ABSTRACT
, ,
 NATURAL NANOMOTORS: MEDICO-BIOLOGICAL TREATM...
Article is devoted to a new direction of nanopharmacology - functioning nanoparticles, nanocomposites comprising nanomotors that mimic the dynamics of natural motors. The natural nanomotors include ATP-ase. Degree of activation of ATP-ase protein kin...
ABSTRACT