RESEARCH PAPER
Occupational acquisition of methicillin-resistant Staphylococcus aureus in humans – A description of MRSA carrier and infected cases from the Region of North Jutland in Denmark
 
 
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Department of Occupational Medicine, Aalborg Hospital, Århus University Hospital, Danish Ramazzini Centre, Alborg, Denmark
 
 
Ann Agric Environ Med. 2012;19(4):637-640
 
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ABSTRACT
Since 2006 in Denmark, there has been a statutory order on physicians’ notification of methicillin-resistant Staphylococcus aureus (MRSA). Occupational cases notified in North Denmark Region in 2008 and 2009 were analysed. Overall, 109 cases (54 females and 55 males) were notified, of whom 56 were infected and 52 cases were carriers, whereas in one case the status was unknown. The most prevalent clonal complex (CC) was 398 (n=26; 23.9%), followed by CC5 (n=17; 15.6%), CC30 (n=14; 12.8%), and CC8 (n=12; 11%). Eighteen cases were occupational with a predominance of CC398 (n= 16; 88.8%); CC8 and CC22 accounted for one case each. There was a significantly higher proportion of occupational cases for CC398 compared with other clonal complexes (p<0.001). All CC398 occupational cases were either farmers or farm workers occupied in swine confinement buildings. The two other cases were nurses working in the region’s public hospitals. Most occupational cases were carriers (n=15; 83%). Three were infected, two with impetigo and one with tonsillitis; CC398 was the causative agent in all three cases. CC398 has a porcine reservoir which is huge in Denmark with a total annual production of 27,700,000 pigs. The presented population-based retrospective study shows an infectious potential of CC398 in humans. Close monitoring of future trends in prevalence, occupational distribution and pathogenicity is still warranted.
 
REFERENCES (29)
1.
Jerons MP. Celbenin – resistant Staphylococci. BMI 1961;1:124-25.
 
2.
Turlej A, Hryniewicz W, Empel J. Staphylococcal Casette Chromosome mec (SCC mec) classi cation and typing methods: an overview. Pol J Microbiol. 2011; 60: 95-103.
 
3.
Tiemersma EW, Bronzwater SL, Lyytikainen O, Degener JE Schrijnemakers P, Bruinsma N, et al. Methicillin-resistant Staphylococcus aureus in Europe, 1999-2002. Emerg Infect Dis. 2004; 10: 1627-34.
 
4.
Kluytmans-Vandenbergh MF, Kluytmans JA. Community-acquired methicillin-resistant Staphylococcus aureus: current perspectives. Clin Microbiol Infect. 2006; 12(Suppl 1): 9-15. DOI:10.1111/j.1469-0691.2006.01341.x.
 
5.
Askarian M, Zeinalzadeh A, Japoni A, Alborzi A, Memish ZA. Prevalence of nasal carriage of methicillin-resistant Staphylococcus aureus and its antibiotic susceptibility pattern in healthcare workers at Namazi Hospital, Shiraz, Iran. Int J Infect Dis. 2009 Sep; 13(5): e241-7. Epub 2009 Mar 9.
 
6.
Haamann F, Dulon M, Nienhaus AI. MRSA as an occupational disease: a case series. Int Arch Occup Environ Health. 2011 Mar; 84(3): 259-66. Epub 2011 Jan 7.
 
7.
Wulf M, van Nes A, Eikelenboom-Boskamp A, de Vries J, Melchers W, Klaassen C, Voss A. Methicillin-resistant Staphylococcus aureus in veterinary doctors and students, the Netherlands. Emerg Infect Dis. 2006 Dec; 12(12): 1939-41.
 
8.
Aiello AE, Lowy FD, Wright LN, Larson EL. Meticillin-resistant Staphylococcus aureus among US prisoners and military personnel: review and recommendations for future studies. Lancet Infect Dis. 2006 Jun; 6(6): 335-41.
 
9.
Voss A, Loe en F, Bakker J, Wulf M, Klaassen C. Methicillin-resistant Staphylococcus aureus in pig farming. Emerg Infect Dis. 2005; 11: 1965-66.
 
10.
Weese JS, Archambault M, Willey BM, Hearn P, Kreiswirth BN, Said-Salim B, et al. Methicillin-resistant Staphylococcus aureus in horses and horse personnel, 2000-2002. Emerg Infect Dis. 2005 Mar; 11(3): 430-5.
 
11.
Larsen AR, Stegger M, Sørum M. spa typing directly from a mecA, spa and pvl multiplex PCR assay-a cost-e ective improvement for methicillin-resistant Staphylococcus aureus surveillance. Ciln Microbiol Infect 2008; 14: 611-14.
 
12.
Stenhem M, Ortqvist A, Ringberg H, Larsson L, Olsson-Liljequist B, Haeggman S, Kalin M, Ekdahl K; Swedish study group on MRSA epidemiology. Validity of routine surveillance data: a case study on Swedish noti cations of methicillin-resistant Staphylococcus aureus. Euro Surveill. 2009 Jul 30; 14(30): 19281.
 
13.
Smith TC, Pearson N. e Emergence of Staphylococcus aureus ST398. Vector Borne Zoonotic Dis. 2011; 11: 327-39.
 
14.
Guardabaasi L, Stegger M, Skov R. Retrospective detection of methicillin resistant and susceptible Staphylococcus aureus ST398 in Danish slaughter pigs. Vet Microbiol. 2007; 122: 384-86.
 
15.
Lewis HC, Mølbak K, Reese C, Aarestrup FM, Selchau M, Sørum M, Skov RL. Pig as source of Methicillin-resistant Staphylococcus aureus CC398 infections in humans, Denmark. Emerg Infect Dis. 2008; 14: 1383-89.
 
16.
van Duijkeren E, Ikawaty R, Brokenhuizen-Stins MJ, et al. Transmission of methicillin-resistant Staphylococcus aureus strains between di erent kinds of pig farms. Vet Microbiol. 2007; 11: 711-14.
 
17.
Huijsdens XW, van Dijke BJ, Spalburg E, van Santen-Verheuvel MG, Heck MEOC, et al. Community-acquired MRSA and pigfarming. Ann Clin Microbiol Antimicrob. 2006; 5: 1-4.
 
18.
Hartmeyer GN, Gahrn-Hansen B, Skov RL, Kolmos HJ. Pig associated methicillin-resistant Staphylococcus aureus: Family transmission and severe pneumonia in newborn. Scan J Inf Dis. 2010; 42: 318-20.
 
19.
Pan A, Battisti A, Zoncada A, Bernieri F, Boldini M, Franco A, et al. Community-acquired methicillin-resistant Staphylococcus aureus ST398 infection, Italy. Emerg Infect Dis. 2009; 5: 845-47.
 
20.
van Belkum A, Melles DC, Peeters JK, van Leeuwen WB, van Duikeren E, Huijsdens XW, et al. Dutch Working Part on Surveillance and Research on MRSA-SOM. Methicillin-resistant and –susceptible Staphylococcus aureus sequence type 398 in pigs and humans. Emerg Infect Dis. 2008; 14: 479-83.
 
21.
Witte W, Strommenger B, Stanec C, Cuny C. Methcillin-resistant Staphylococcus aureus ST398 in humans and animals, Central Europe. Emerg Infect Dis. 2007; 2: 255-58.
 
22.
Wulf M, Voss A. MRSA in livestock animals – an epidemic waiting to happen? Clin Microbiol Infect. 2008; 6: 519-21.
 
23.
Grisold AJ, Zarfel G, Stoeger A, Feierl G, Raggam RB, Marth E. Emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in Southeast Austria. J Infect. 2009; 2: 168-70.
 
24.
van Rijen MM, Van Keulen PH, Kluytmans JA. Increase in a Dutch hospital of methicillin-resistant Staphylococcus aureus related to animal farming. Clin Infect Dis. 2008; 2: 261-63.
 
25.
Krziwanek K, Metz-Gercek S, Mittermayer H. Methicillin-Resistant Staphylococcus aureus ST398 from humans patients, upper Austria. Emerg Infect Dis. 2009; 5: 766-69.
 
26.
www.danmap.org/pdfFiles/Danmap2009.pdf. (access: 15 December 2011).
 
27.
www.sickpigs.dk/user les/ le/mrsa%20i%stigning.pdf. (access: 15 December 2011).
 
28.
Aarestrup FM, Cavaco L, Hasman H. Decreased susceptibility to zinc chloride is associated with methicillin resistant Staphylococcus aureus CC398 in Danish swine. Vet Microbiol. 2010; 142: 455-57.
 
29.
www.dst.dk/pukola/epub/Nyt/2010/NR186.pdf. (access: 18 December 2011).
 
eISSN:1898-2263
ISSN:1232-1966
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