Influence of chlorpyrifos on the profile of subpopulations of immunoactive cells and their phagocytic activity in an experimental in vivo model

Justyna Noworyta-Głowacka 1, Robert Bańkowski 1, Joanna Siennicka 2, Bożena Wiadrowska 1, Martyna Beresińska 1, Jan Krzysztof Ludwicki 1
1 - Department of Toxicology and Risk Assessment, National Institute of Public Health – National Institute of Hygiene, Warsaw, Poland
2 - Department of Virology, National Institute of Public Health – National Institute of Hygiene, Warsaw, Poland
Ann Agric Environ Med
2012; 19 (3):
ICID: 1011074
Article type: Original article
 
 
Many environmental factors, including pesticides, cause immunological system disorders by inducing changes in humoral and cellular response. They may stimulate or trigger immunological autoaggression, hypersensitivity and allergy, as well as lead to immunosuppression, thus increasing the incidence of infectious diseases and cancers. Such activity is also attributed to organophosphorus compounds used in agriculture as insecticides, and commonly in households as biocides. The aim of the study was to define possible mechanisms of the immunotoxic activity of the chlorpyrifos (an organophosphorus compound) on experimental animals following their exposure to the compound via the oral route. The present study attempts to define the influence of chlorpyrifos on the profile of subpopulations of immunoactive cells: B, T, CD4+, CD8+, and NK, and on their phagocytic activity in an experimental in vivo model. For this purpose, the Wistar rats, were exposed orally to increasing doses of chlorpyrifos: 0.1 LD50, 0.15 LD50, 0.2 LD50, 0.3 LD50 and 0.4 LD50 for 28 days. In the study animals, we failed to demonstrate a statistically significant decrease in the phagocytic activity of the granulocyte.
PMID 23020043 - click here to show this article in PubMed
  FULL TEXT STATS

Recommend this article to:

Name:
E-mail:
From:
Language:


Related articles in IndexCopernicus™
     phagocytic activity [2 related records]
     B lymphocytes [4 related records]
     T lymphocytes [30 related records]
     Immunomodulation [52 related records]



 

Related articles

B Sharma, A Kumar,
 ...
 ...
ABSTRACT
J Piotrowski, T Jędrzejewski,
Immunomodulatory and antitumor properties of polys...
Modern medicine successfully uses multiple immunomodulators of natural origin, that can affect biological reactions and support body’s natural defense mechanisms including antitumor activities. Among them is a group of products derived from fungi, ...
ABSTRACT
M HAN, L YANG,
 Cbl-b gene silencing enhances the ability of...
 Objective: To use specific small interfering RNA (siRNA) targeting casitas B cell lymphoma-b (Cbl-b) gene to silence the expression of Cbl-b in T lymphocytes in mice, and investigate the immune killing activity of T lymphocytes against mouse br...
ABSTRACT