Is the advancement of diabetic angiopathy evaluated as ankle-brachial index directly associated with current glycaemic control?

Piotr Dziemidok 1, Grzegorz Szcześniak 2, Ewa Kostrzewa-Zabłocka 2, Piotr Paprzycki 3, Anna Korzon-Burakowska 4
1 - Diabetology Department, Institute of Rural Health, Lublin, Poland; Institute of Public Health, Pope John Paul II State School of Higher Education in Biała Podlaska, Poland
2 - Diabetology Department, Institute of Rural Health, Lublin, Poland
3 - Department of Functional Research, Institute of Rural Health, Lublin, Poland
4 - Department of Hypertension and Diabetology, Medical University, Gdańsk, Poland
Ann Agric Environ Med
2012; 19 (3):
ICID: 1010944
Article type: Original article
Introduction and objective: Diabetic patients are at high risk for peripheral arterial disease (PAD) characterized by symptoms of intermittent claudication or critical limb ischemia. Measurement of ankle-brachial index (ABI) has emerged as the diagnostic tool of choice, because it is relatively simple, non-invasive and inexpensive. It is also an independent marker of increased morbidity and mortality from cardiovascular diseases. The aim of the presented study was to assess the relationship between current glycemic control defined by glycated hemoglobin (HbA1c) level, and quantitative changes in the arteries of the lower limbs in patients with type 2 diabetes.
Materials and methods: 175 patients with type 2 diabetes hospitalized in the Diabetology Ward were studied. VENO Doppler and a sphygmomanometer were used to assess blood flow.
Results: The average level of HbA1c was assessed at 8.48%. Although the average level of ABI indicator was 1.20 (normal), only 45% of evaluated patients had their individual index within the normal range. Signs of ischemia were found in 17.7% of examined subjects. There was no conclusive correlation between ABI and HbA1c levels.
Conclusions: The current level of glycemic control evaluated as HbA1c has no direct impact on the advancement of diabetic angiopathy evaluated as ABI.
PMID 23020057 - click here to show this article in PubMed

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