Immune changes in animal breeders: a pilot study conducted in northern Italy

Ramin Tabibi 1, Emanuela Corsini 2, Gabri Brambilla 1, Luigi Bonizzi 3, Gianlodovico Melzi d’Eril 4, Giulia Rabozzi 1, Maryam Sokooti 1, Luisa Romanò 5, Chiara Somaruga 1, Francesca Vellere 1, Alessandro Zanetti 5, Claudio Colosio 1
1 - Department of Occupational and Environmental Health, University of Milan, International Centre for Rural Health, University Hospital San Paolo, Milan, Italy
2 - Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Italy
3 - Department of Animal Pathology, Hygiene and Veterinary Public Health, University of Milan, Italy
4 - Department of Medicine, Surgery and Dentistry, University of Milan, Italy
5 - Department of Public Health – Microbiology – Virology, University of Milan, Italy
Ann Agric Environ Med
2012; 19 (2):
ICID: 1001992
Article type: Original article
 
 
Objective: Farming is associated with exposure to a wide variety of risk factors including organic dusts, endotoxins, allergens and other chemicals. The ability of some of these agents to interact with the immune system is demonstrated in the presented study which was undertaken to evaluate the relationship between pig and cow breeding, and the immune system early changes. Particular attention is paid to selected serum cytokines.
Methods: Sixty four animal breeders (36 cattle and 28 pig breeders) were selected as the exposed group, and 32 rural workers not engaged in animal breeding were utilised as the controls. Personal data were collected through a questionnaire, and selected serum parameters measured, including cytokines IL-6, IL-8, IL-10, IFNγ and TNFα, immunoglobulins and proteins, and total and differential white blood cell counts.
Results: The study stresses the significant increase of TNF-α, IL-8, and IL-10 in animal breeders, with the highest values in pig breeders, and a slight but statistically significant increase in albumin and total serum proteins.Conclusions: The findings of the presented study suggest a condition of immune system activation in animal breeders, with the highest levels observed in pig breeders. These changes may be attributable to exposure to organic dusts, endotoxins, or to the different biological agents present in the rural environment. The prognostic significance of these findings, however, remains unclear, but the observed changes might be indicative of a risk of developing respiratory toxic and allergic diseases, which need to be further investigated.
PMID 22742791 - click here to show this article in PubMed
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